Results 41 to 50 of about 11,738,095 (218)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Preparedness needs of German municipal public health authorities
Human Biology and Public HealthBackground Recent crises have shown how complex threats to population health have become. Disease outbreaks, climate-related disasters, geopolitical tensions and disruptions to critical infrastructure do not occur in isolation: they overlap and ...
Raoul Maximilian Hecker +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 1898 E flat majorTempo di Marcia, molto ...
http://id.loc.gov/authorities/names/n79140961 +1 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Communication and the financial decisions made by public authorities
Prawo Budżetowe Państwa i Samorządu, 2017 The main purpose of this article is to assess an impact of communication between public authority and a society about financial decision-making by that authority.
Joanna M. Salachna, Marcin Tyniewicki
doaj +1 more source
THE PRIORITY OF PUBLIC INTEREST PRINCIPLE IN THE PUBLIC PROCUREMENT CONTRACTS [PDF]
Challenges of the Knowledge Society, 2021 Important by object, value and general interest for which they are concluded, the public procurement contracts have a dual nature, although they are most often qualified as administrative contracts, with particular characteristics.
Viorel ROȘ, Andreea LIVĂDARIU
doaj
, 1921 F majorAllegro moderato4934-9Adapted from melodies of Franz Schubert and Heinrich Berté; Produced by Shubert Brothers, Lee (1873-1953) and J.J. (1879-1963); Original text by A.M.
Schubert, Franz, 1797-1828; Berté, Heinrich +1 more
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source