Results 231 to 240 of about 1,610,859 (302)

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Onset and exacerbation of obsessive-compulsive disorder in the perinatal period. [PDF]

Arch Womens Ment Health
Samuels J, Kimmel M, Krasnow J, Musci R, Nestadt PS, Osborne LM, Storch EA, Abramowitz JS, Nestadt G.   +8 more
europepmc   +1 more source

The Impact of Trust in Science on COVID-19 Vaccine Attitudes: Parallel Mediation Through Conspiracy Beliefs and General Vaccine Hesitancy. [PDF]

Eurasian J Med
Kara S, Hatipoğlu SS, Arslanoğlu NZ, Erdoğan Z.   +3 more
europepmc   +1 more source

Capybaras (<i>Hydrochoerus hydrochaeris</i>) in the City: Understanding Urban Coexistence, Management Strategies and the Animal Welfare Implications. [PDF]

Animals (Basel)
Nunes Sayn KM, Hötzel MJ, Nogueira SSC.
europepmc   +1 more source

Implementation of a Self-Management Approach for Low Back Pain in a Public Health Care System.

JAMA Netw Open
Feldman R, Pincus T, Reges O, Gorelik A, Buchbinder R, Ben Ami N.   +5 more
europepmc   +1 more source

I Told You So! Verbal cue beliefs are associated with truth detection, but not lie detection. [PDF]

PLoS One
Bogaard G, Fieweger SE, Meijer EH.
europepmc   +1 more source

Changes in firearm intentions and behaviors after the 2024 United States presidential election. [PDF]

Inj Epidemiol
Anestis MD, Bond AE, Burke KC, Altikriti S, Semenza DC.   +4 more
europepmc   +1 more source

When noise mitigates bias in human-algorithm decision-making: An agent-based model. [PDF]

PLoS One
Poodiack Parsons S, Torenvlied R.
europepmc   +1 more source