Results 241 to 250 of about 2,254,914 (312)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

A qualitative study of the social and structural vulnerabilities of HIV and chronic disease syndemics in low-resource urban health facilities in South Africa. [PDF]

Discov Public Health
Bulled N, Nyatela A, Nonyukela S, Lalla-Edward S.   +3 more
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Voting intentions during the later stage of the COVID-19 pandemic: The roles of risk perception and performance evaluations in South Korea. [PDF]

PLoS One
Kim SY, Kim G, Park S, Kim C, Jang DH, Joe DH, Jang WM.   +6 more
europepmc   +1 more source

Effect of online digital storytelling on the comprehension of authentic listening materials and engagement of junior high school EFL learners. [PDF]

Sci Rep
Wang W, Zheng L, Zhang J.
europepmc   +1 more source

From Guidelines to Practice: Case-Based Teaching Module to Improve MASLD Screening in Diabetes Care for Internal Medicine Residents. [PDF]

MedEdPORTAL
Liu B, Orakwue C, Ryan K, Manolas MI, Kumar S.   +4 more
europepmc   +1 more source

A national randomized controlled trial of the impact of public Montessori preschool at the end of kindergarten. [PDF]

Proc Natl Acad Sci U S A
Lillard AS, Loeb D, Berg J, Escueta M, Manship K, Hauser A, Daggett ED.   +6 more
europepmc   +1 more source

Visible Pregnancy, Invisible HIV: How Social Norms Shape Adolescents Protection Choice in Kenya and Nigeria. [PDF]

Ann Glob Health
Bitère C, Ifenna RJ, Gebrehanna H, Ombasa DN.   +3 more
europepmc   +1 more source

On flexible covariate adjustment under covariate-constrained randomization. [PDF]

Clin Trials
Wang B, Li F.
europepmc   +1 more source

Representation gap for transition factors from social sciences in energy and emissions modeling

Kunnas S, Trutnevyte E.
europepmc   +1 more source