Results 141 to 150 of about 27,380 (293)
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Mommy Groups as Sites for Deliberation in Everyday Speech
, 2014 This study advances our knowledge of the role of metaphor in deliberation in everyday speech (with an emphasis on the role of competition, cooperation, and connection metaphors), which up to now has not been studied as an important discursive strategy in
Lawrence, Windy Yvonne, Ph.D. +1 more
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Advanced Science, EarlyView.ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo +14 more
wiley +1 more source
Deliberation in Democracy\u27s Dark Times
, 2018 This piece reflects on the on the legacies of democratic deliberation, particularly mini-publics in responding to issues of disinformation, bigotry and nativism that has entered the political mainstream today.
Parry, Lucy J, Curato, Nicole
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Advanced Science, EarlyView.Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang +32 more
wiley +1 more source
The People’s Lobby: A Model for Online Activist Deliberation
, 2013 This article presents a model for a “People’s Lobby,” a digital process of deliberation and activism that allows citizens to have their voices heard on important political issues.
Swift, Jeffrey C
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Disorder‐Induced Extremely Low Thermal Conductivity of Graphite Fluoride
Advanced Science, EarlyView.This article investigates the effect of fluorination on the thermal conductivity of graphite fluoride, demonstrating the relationship between structural modification and thermal conductivity in an extreme case. The record‐low through‐plane thermal conductivity measured in exfoliated graphite fluoride flakes was found to correlate with the wide ...
Wonsik Lee +10 more
wiley +1 more source
Avoiding a Tyranny of the Majority: Public Deliberation as Citizen Science, Sensitive Issues, and Vulnerable Populations. [PDF]
Am J Bioeth, 2019 Ott MA, Knopf AS.
europepmc +1 more source
, 2018 This essay develops a theory of public dialogue and deliberation as agonistic resistance to authoritarian governance.Where authoritarian regimes value strict obedience to authority at the expense of freedom, deliberative democracy is predicated on the ...
Wolfe, Anna Wiederhold
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Advanced Science, EarlyView.An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong +14 more
wiley +1 more source