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PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

open access: yesAdvanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang   +10 more
wiley   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

open access: yesAdvanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li   +7 more
wiley   +1 more source

Men's Preferences for Exiting Abdominal Aortic Aneurysm Surveillance: A Deliberative Engagement Session Study. [PDF]

open access: yesPatient Prefer Adherence
Hughes J   +11 more
europepmc   +1 more source

Unleashing the transformative power of deliberation with contextual citizens. [PDF]

open access: yesPhilos Trans A Math Phys Eng Sci
Lambert-Mogliansky A, Frérot I.
europepmc   +1 more source

Don't give up on politics. [PDF]

open access: yesEur J Public Health
Burris S.
europepmc   +1 more source

Harnessing Medical Bioethics Mediation to Advance One Health Governance. [PDF]

open access: yesVet Sci
Lioupi O   +5 more
europepmc   +1 more source

Intuitive and deliberative processes underlying commitment signaling for cooperative assortment. [PDF]

open access: yesiScience
Lang M   +4 more
europepmc   +1 more source

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