Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang +5 more
wiley +1 more source
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng +6 more
wiley +1 more source
Framing health inequalities through the political economy: a case study of Ethiopia's public policy landscape. [PDF]
Dobamo AG.
europepmc +1 more source
Public Expenditure Policy in Bolivia: Growth and Welfare [PDF]
It has been widely documented that fiscal policy can promote economic growth, when it is based on an efficient provision of pubic capital. But little work has been done, in Bolivia, in relation to the macroeconomic and sectoral impacts of increasing ...
Carlos Gustavo Machicado +2 more
core
This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim +5 more
wiley +1 more source
Does digital economy affect the happiness of older adults? [PDF]
Wu Z +5 more
europepmc +1 more source
Public Choice, Constitutional Political Economy and Law and Economics [PDF]
The various subdisciplines within the emerging ‘new institutionalism’ in economics all draw special attention to the legal-political constraints within which economic and political agents choose and therefore represent a return of economics to its ...
Ludwig van den Hauwe
core
Beyond the Ban—Shedding Light on Smallholders' Price Vulnerability in Indonesia's Palm Oil Industry
ABSTRACT The Indonesian government imposed a palm oil export ban in April 2022 to address rising cooking oil prices. This study explores oil palm smallholders' vulnerability to the policy using descriptive statistics, Lasso, and post‐Lasso OLS regressions.
Charlotte‐Elena Reich +3 more
wiley +1 more source
Assessing Law No. 87 of 2024 on private sector management of public healthcare facilities in Egypt: neoliberal roots, potential consequences, and policy recommendations. [PDF]
Abu El Kheir-Mataria W +2 more
europepmc +1 more source
Popular Reaction to the Intervention by the IMF in the Korean Economic Crisis [PDF]
The International Monetary Fund (IMF) has played an important role in restructuring the Korean economy over the past three years. Relying upon survey data collected in 1998 and 1999, this paper explores the role of the IMF in Korea, as perceived by its ...
Bernd Hayo, Doh Chull Shin
core

