Results 51 to 60 of about 85,514 (215)

Proper interactive communication of the police as a(n e-)trust-building strategy Introducing the term policing digilect [PDF]

Košická bezpečnostná revue, 2020
Media channels play an indisputable role in the credibility and accuracy of information about security risks and deficiencies in the world around us. Social media sites as media channels are also being paid much attention nowadays.
Erna URICSKA
doaj  

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

EL DESEMPEÑO EN JUICIO DE LA FNE: ¿ES REALMENTE UN MEJOR LITIGANTE QUE LOS DEMANDANTES PRIVADOS?

Revista de Derecho (Coquimbo)
Este documento analiza el desempeño como litigante de la Fiscalía Nacional Económica ("FNE"), proponiendo un enfoque que sistematiza sus diferencias con los demandantes privados en términos del esfuerzo que cada uno debiera desplegar en un juicio.
DIEGO G PARDOW
doaj   +1 more source

Individuals and the Enforcement of Competition Law – Recent Development of the Private Enforcement Doctrine in Polish and European Antitrust Law [PDF]

Yearbook of Antitrust and Regulatory Studies, 2015
The following article focuses on the issue of private enforcement of competition law as one of the key elements of the current European and national debate on the efficiency of competition law. By analyzing this concept, the article aims to determine the
Maciej Gac
doaj  

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

PROCEDURAL LIABILITY AS A LEGAL PHENOMENON

Russian Journal of Economics and Law, 2015
Objective: basing on the research of existing doctrinal developments, current legislation and law enforcement practices, to analyze the place and role of procedural liability in the system of legal liability, to develop recommendations on improvement of ...
N. V. Makareyko
doaj  

The Interaction between EU Competition Law Procedures and Fundamental Rights Protection: the Case of the Right to Be Heard [PDF]

Yearbook of Antitrust and Regulatory Studies, 2014
This paper analyses the jurisprudence of the European Court of Human Rights on the rights of defence as enshrined in Article 6 of the European Convention on Human Rights. In particular, it assesses Strasbourg jurisprudence on the right to be heard and on
Elsbeth Beumer
doaj  

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Does private enforcement constrain falsified statements? Evidence from the abolition of the procedural prerequisite for civil litigation in China

China Journal of Accounting Studies
A central challenge in studying the relationship between private enforcement and falsified statements lies in identifying an exogenous shock that affects the intensity of private enforcement for specific firms in isolation. Document No. 185 [2020] issued
Chun Liu, Liang Sun
doaj   +1 more source