Results 81 to 90 of about 6,256,801 (344)

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang   +12 more
wiley   +1 more source

The Impact of EU Law on a National Competition Authority’s Leniency Programme – the Case of Poland [PDF]

open access: yesYearbook of Antitrust and Regulatory Studies, 2014
This paper is devoted to the impact of EU law on national leniency programmes, especially the Polish one. It analyses the jurisprudence of the Court of Justice in Pfleiderer, Donau Chemie and Schenker and identifies three specific areas of potential EU ...
Piotr Sitarek
doaj  

Private versus Public Enforcement of Fines [PDF]

open access: yes
The present paper analyzes the competitive, monopolistic, and public enforcement of fines allowing for the costs of enforcement to differ by the choice of the enforcer. There are a number of reasons to expect such differences.
A. Mitchell Polinsky
core  

Nanozymes Integrated Biochips Toward Smart Detection System

open access: yesAdvanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen   +10 more
wiley   +1 more source

Public administration in the field of law-enforcement activity

open access: yesЕкономіка, управління та адміністрування, 2019
The article is devoted to the peculiarities of public administration features formation in the conditions of strategic changes. The article focuses on the law enforcement agencies’ role in public administration in Ukraine.
V.О. Kuchmenko   +2 more
doaj   +1 more source

Evolution of public cooperation in a monitored society with implicated punishment and within-group enforcement

open access: yes, 2015
Monitoring with implicated punishment is common in human societies to avert freeriding on common goods. But is it effective in promoting public cooperation?
Chen, Xiaojie   +2 more
core   +1 more source

Neural Fields for Highly Accelerated 2D Cine Phase Contrast MRI

open access: yesAdvanced Science, EarlyView.
ABSTRACT 2D cine phase contrast (CPC) MRI provides quantitative information on blood velocity and flow within the human vasculature. However, data acquisition is time‐consuming, motivating the reconstruction of the velocity field from undersampled measurements to reduce scan times. In this work, neural fields are proposed as a continuous spatiotemporal
Pablo Arratia   +7 more
wiley   +1 more source

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

open access: yesAdvanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang   +14 more
wiley   +1 more source

Does Government Regulation Complement Existing Community Efforts to Support Cooperation? Evidence from Field Experiments in Colombia [PDF]

open access: yes
In this paper we describe a field experiment conducted among mollusk harvesters in a community on the Pacific Coast of Columbia. The experiment is based on a standard linear public good and consists of two stages.
James J. Murphy   +3 more
core  

Improving voluntary public good provision by a non-governmental, endogenous matching mechanism : experimental evidence [PDF]

open access: yes, 2014
Social norms can help to foster cooperation and to overcome the free-rider problem in private provision of public goods. This paper focuses on the enforcement of social norms by a self-introduced punishment and reward scheme.
Löschel, Andreas   +2 more
core   +4 more sources

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