Results 191 to 200 of about 509,129 (268)

Structured digital health intervention for leprosy awareness: a case study of analyzing public engagement and sentiment in a Sri Lankan leprosy awareness campaign on Facebook. [PDF]

BMC Infect Dis
Wijesinghe MSD, Pathirana A, Karawita UG, Nissanka NAKAI, Hewapathirana AIS, Kahawita IP, Ranaweera KDNP, Alagiyawanna AMMAP.   +7 more
europepmc   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Benefits of public engagement in research and barriers to participation: a UK-based survey of academic scientists and support staff including international respondents. [PDF]

Immunol Cell Biol
Ogbukagu CM, Eberl M, Joseph-Williams N, Hatch S, Tyrrell JM.   +4 more
europepmc   +1 more source

Lived Experience Engagement

The Amplify Engagement Report presents findings from the Children with Incarcerated Parents (CHIRP) study, which aims to estimate the number of children affected by parental incarceration across five Canadian provinces (British Columbia, Alberta ...
Engagement, Amplify
core  

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Integrating public engagement to promote transparent data use in a new UK-wide birth cohort. [PDF]

Int J Popul Data Sci
Raybould A, Dennison K, McBride O, Wong E, Calderwood L, Fearon P, Goodman A.   +6 more
europepmc   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Study Protocol for the PARTICIPATE Project: Co-Creating Resources for Public Engagement in Maternity Care Clinical Audit and Learning. [PDF]

Health Expect
Escañuela Sánchez T, San-Lázaro Campillo I, McKernan J, Corcoran P, Greene RA, PARTICIPATE Project Advisory Group.   +5 more
europepmc   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Cultivating awareness: How botanical gardens can foster public engagement with plant pathogens. [PDF]

PLoS Pathog
Hann DR, Kadereit G.
europepmc   +1 more source