Results 251 to 260 of about 7,127,786 (370)

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

open access: yesAdvanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu   +11 more
wiley   +1 more source

Why should we promote public engagement with science? [PDF]

open access: green, 2014
Jack Stilgoe   +2 more
openalex   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

open access: yesAdvanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong   +9 more
wiley   +1 more source

A social science research agenda to accelerate public engagement in climate change adaptation. [PDF]

open access: yesFront Psychol, 2023
Harcourt R   +3 more
europepmc   +1 more source

Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

open access: yesAdvanced Science, EarlyView.
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang   +10 more
wiley   +1 more source

Reconciling market and moral logics on a minimum wage: Supermarket work in Australia during the first two years of the SARS-COV-2 pandemic

open access: yesSSM: Qualitative Research in Health
Essential workers generate and maintain basic services that populations must receive, without interruption, to sustain a healthy, functional society. When SARS-COV-2 spread around the world, mundane low-paid work in essential non-healthcare industries ...
Chris Degeling   +5 more
doaj  

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