Results 41 to 50 of about 403,247 (253)

Community perspectives on the benefits and risks of technologically enhanced communicable disease surveillance systems: a report on four community juries

BMC Medical Ethics, 2020
Background Outbreaks of infectious disease cause serious and costly health and social problems. Two new technologies – pathogen whole genome sequencing (WGS) and Big Data analytics – promise to improve our capacity to detect and control outbreaks earlier,
Chris Degeling, Stacy M. Carter, Antoine M. van Oijen, Jeremy McAnulty, Vitali Sintchenko, Annette Braunack-Mayer, Trent Yarwood, Jane Johnson, Gwendolyn L. Gilbert   +8 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Advancing engagement and capacity for rural cancer control: a mixed-methods case study of a Community-Academic Advisory Board in the Appalachia region of Southwest Virginia

Research Involvement and Engagement, 2021
Plain English summary There has been notable progress among state and local cancer coalitions in developing and implementing comprehesive cancer control plans.
Jamie M. Zoellner, Kathleen J. Porter, Donna-Jean P. Brock, Emma Mc Kim Mitchell, Howard Chapman, Deborah Clarkston, Wendy Cohn, Lindsay Hauser, Dianne W. Morris, Sarah Y. Ramey, Brenna Robinson, Scott Schriefer, Noelle Voges, Kara P. Wiseman   +13 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

A wave glider for passive acoustic monitoring of cetaceans and anthropogenic sources in the central Mediterranean Sea

Scientific Reports
Passive acoustic monitoring has become a widely used method to study cetaceans, especially for populations facing escalating threats from noisy human activities, including shipping traffic, fishing industry and marine constructions.
Sara Ferri, Anaëlle Evrard, Simonepietro Canese, Teresa Romeo, Silvestro Greco, Augusto Passarelli, Livio Favaro, Francesco Caruso   +7 more
doaj   +1 more source

JAGRITI (ಜಾಗೃತಿ) - A study on enhancement of health communication for sickle cell disease (SCD) among Soliga Indigenous community in Chamarajanagar, Karnataka: Study protocol [version 1; peer review: 2 approved]

Wellcome Open Research
Background Sickle Cell Disease (SCD) is a genetic disorder that disproportionately affects Indigenous populations. Tailored awareness and management strategies are crucial for reducing the prevalence of SCD and improving its management.
Deepa Bhat, Padmakumar K, Praveen Srinivasa Rao, Yogish Channa Basappa, Manjula Venkataraghavan, Achyutha Nagaragadde, Upendra M Bhojani, Tanya Seshadri   +7 more
doaj   +1 more source