Results 211 to 220 of about 12,141,356 (259)

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

open access: yesAdvanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu   +15 more
wiley   +1 more source

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis‐Associated Metabolic Disorders in a GPR81‐Dependent Manner

open access: yesAdvanced Science, EarlyView.
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng   +4 more
wiley   +1 more source

Propofol Modulates Fear Memory Reconsolidation by Inhibiting D2 Receptor‐Expressing Neurons in the Medial Prefrontal Cortex

open access: yesAdvanced Science, EarlyView.
This study shows that propofol modulates fear‐memory reconsolidation in mice. It works by suppressing D2 receptor‐expressing neurons within the medial prefrontal cortex and their connections to the basolateral amygdala. D2‐receptor agonists reproduce this fear‐reducing effect, offering potential non‐anesthetic therapeutic strategies for trauma‐related ...
Jie Li   +11 more
wiley   +1 more source

Accelerating High‐Fidelity Airfoil Design via Physics‐Informed Video Diffusion Model

open access: yesAdvanced Science, EarlyView.
Physics‐informed video diffusion enables rapid inverse aerodynamic design by mapping target lift‐to‐drag response to airfoil geometries and full‐field flow distributions. Trained on 53 400 DNS samples, the model achieves over 90% fidelity with ∼30 s inference, while experimentally realized propeller designs demonstrate a practical pathway from ...
Yifeng Ai   +9 more
wiley   +1 more source

Extended cost-effectiveness analysis in global health systems: a scoping review of geographic gaps and research trends. [PDF]

open access: yesCost Eff Resour Alloc
Najafi S   +6 more
europepmc   +1 more source

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