Results 151 to 160 of about 391,220 (294)

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Consensus Formation and Change are Enhanced by Neutrality

Advanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag, Janina A. Hoffmann, Tim Rogers, Christian A. Yates   +3 more
wiley   +1 more source

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source

Violating public finance discipline in the local government unit as the object of internal audit [PDF]

Zeszyty Naukowe Uniwersytetu Szczecińskiego Finanse, Rynki Finansowe, Ubezpieczenia, 2015
openaire   +1 more source

Non-Compliance with Budgetary Reporting Obligations in Local Government Units and Liability for Breach of Public Finance Discipline

Przegląd Prawa Administracyjnego, 2022
openaire   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Naruszenie dyscypliny finansów publicznych w zakresie wykorzystania subwencji ogólnej / The violation of public finance discipline with respect to the use of general grant [PDF]

Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2016
Alicja Sekuła, Roman Fandrejewski
openaire   +1 more source

The discipline of public finances and its breach in the light of the activity of the Regional Commission at the Regional Chamber of Audit in Bydgoszcz

Prawo Budżetowe Państwa i Samorządu, 2015
The discipline of public finances means the obligation to comply with legal regulations concerning the financial management in the public sector. The financial regulations determine a lot of types of breaches of law in the field of public finances. The study presents a procedure and activity of the Regional Commission at the Regional Chamber of Audit ...
openaire   +1 more source

An Increasing Misalignment Between Crop Distribution and Environmental Resources Under Climate Change in China

Advanced Science, EarlyView.
Climate change reshapes the spatial alignment between crop production and environmental resources. Using multi‐source data and a crop model, integrated climatic, water, and soil endowments for maize and wheat are quantified and compared with harvest distributions.
Zheng'e Su, Zhentao Zhang, Jin Zhao, Xia Liang, Chuang Zhao, Zhijuan Liu, Minghao Zhuang, Jing Sun, Bo Lu, Ke Liu, Johannes W. M. Pullens, Matthew T. Harrison, Deli Chen, Xiaoguang Yang   +13 more
wiley   +1 more source

Not Every Country Can Absorb a Shock: Unequal Capacity to Withstand World Health Organization Aid Cuts. [PDF]

Public Health Chall
Ghimire A.
europepmc   +1 more source