Results 41 to 50 of about 6,913 (243)
Correlation Between Fiscal Rules and Sustainable Development of the Visegrad Group Countries
Problemy Zarządzania, 2019 The research question presented in this analysis focuses on national fiscal rules applicable in the Visegrad Group (also called V4) expressed in the European standardised fiscal rules index and on their impact on the socio-economic policy.
Jens Hölscher +3 more
doaj +1 more source
FISCAL SECURITY OF THE STATE: CONCEPTUAL BASIS FOR A NEW DIRECTION IN ECOSESTATE
Стратегічна панорама, 2020 The article presents conceptual basis and outlines for a new direction in the ecosestate – fiscal security of the state. A range of vital conceptual problems have been addressed in the article, including defining the concept of the fiscal security ...
Aleksy Moldowan
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
A gravity model approach to understand the spread of pandemics: Evidence from the COVID-19 outbreak
Open Health, 2023 Pandemics disrupt the global economy. Understanding the transmission pattern of pandemics informs policies to prevent or reduce the catastrophic consequences associated with pandemics.
Frimpong Albert Opoku +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Gubernaculum et AdministratioThe aim of the article is to present the issue of the use of public funds by a political party in the form of subjective subsidies and subsidies from the state budget. A political party is a voluntary organization of citizens of the Republic of Poland who are at least 18 years old, operating under a specific name, whose goal is to participate in public
Jadwiga Glumińska-Pawlic +1 more
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source