Results 151 to 160 of about 699,861 (259)

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

National Public Health Institutes Organizational Strengthening Module Framework: Applying Organizational Development Principles. [PDF]

Ann Glob Health
Hansoti B, Stodola C, Ridhi S, Adhikari B, Engineer C, Bratton S, Carnevale C, Gilayeneh JSM, Chilengi R, Bennett S.   +9 more
europepmc   +1 more source

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

Accelerating vaccine research and development for skin neglected tropical diseases: A case for leishmaniasis, leprosy, and Buruli ulcer. [PDF]

PLoS Negl Trop Dis
Wang H, Novais FO, Gómez MA, Muhi S, de Oliveira CI, Pham TT, Vermaak S, VALIDATE Network Skin NTDs Working Group, Reljic R.   +8 more
europepmc   +1 more source

PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy

Advanced Science, EarlyView.
Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen, Ming‐Ying Xiao, Lan‐Lan Guo, Hao‐Yue Hu, Sui‐Xian Zhang, Bai‐Qiang Dong, Chen‐Fei Wu, Xia‐Hang Huang, Li Li, Run‐Zhe Chen, Yuan‐Yang Huang, Ying Jin, Hai Song, Ying Wang, Qi‐Wen Li, Ming Chen, Xuan Li, Yuan‐Yuan Chen   +17 more
wiley   +1 more source

Evaluation of a free mail-in opt-out STI testing programme on 3-month rescreening rates in reproductive health centres. [PDF]

Sex Transm Infect
Small SL, Emery JF, Hart V, Tarmey OA, de Jager E.   +4 more
europepmc   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

Closing the Harm Reduction Gap: EMPOWERing People Who Smoke. [PDF]

Cureus
Reese L, Murphy MA, Murray K.
europepmc   +1 more source

Néel‐Vector‐Dependent Unconventional Spin‐Orbit Torque for Deterministic Field‐Free Switching in NiO (110)‐Based Trilayers

Advanced Science, EarlyView.
Unconventional spin currents are generated in an antiferromagnetic NiO(110)/Ta/CoFeB trilayer, where the Néel vector governs spin transport. The resulting spin–orbit torques enable deterministic field‐free switching of perpendicular magnetization.
Hyeong‐Joo Seo, Seok‐Jong Kim, Phuoc Cao Van, Hong‐Cuong Truong, Dong‐Hyeon Han, Geunwoo Kim, Younghun Jo, Jong Hoon Jung, Soojung Kim, Chun‐Yeol You, Jong‐Ryul Jeong, Kyung‐Jin Lee, Byong‐Guk Park   +12 more
wiley   +1 more source

Associations between multidimensional social support and satisfaction with community mental health services: evidence from China with heterogeneity analysis. [PDF]

Front Public Health
Li H, Li H, Liu F.
europepmc   +1 more source