Results 71 to 80 of about 1,703,286 (308)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Identification of Public Goods and Bads in South Central Planning Region in Bulgaria
Икономика и управление на селското стопанство, 2016 The aim of the article is to outline public goods and bads from agriculture and forestry in the South Central Planning Region. There is a wide range of public bads and goods related to agriculture.
DIMITRE NIKOLOV +2 more
doaj
Testing Core Membership in Public Goods Economies
, 2017 This paper develops a recent line of economic theory seeking to understand public goods economies using methods of topological analysis. Our first main result is a very clean characterization of the economy's core (the standard solution concept in public
Anguas-Escalante, Abril +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
How to Analyze Models of Nonlinear Public Goods
Games, 2018 Public goods games often assume that the effect of the public good is a linear function of the number of contributions. In many cases, however, especially in biology, public goods have nonlinear effects, and nonlinear games are known to have dynamics and
Marco Archetti
doaj +1 more source
WHY AND HOW SHOULD THE GOVERNMENT FINANCE PUBLIC GOODS IN RURAL AREAS? A REVIEW OF ARGUMENTS [PDF]
This paper reviews three arguments why government should not directly finance public goods provision in the countryside: (1) sorting and voting of residents leads to efficient local public goods provision, (2) community governance may better cope with ...
Petrick, Martin
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
PARTICULAR ASPECTS OF CONSUMER PROFILE OF THE PUBLIC GOODS GENERATED IN A REGION WITH EXTENSIVE AGRICULTURAL ACTIVITIES: THE CASE OF DORNA VALLEY AREA OF ROMANIA [PDF]
EURINT, 2018 The market of public goods is one of the most particular institutions because both the suppliers and consumers are very heterogeneous. In one of the richest, from public goods point of view, area of Romania, the region of Dorna Valley in the North East ...
Costică MIHAI, Mariana HATMANU
doaj
Samuelson machines and the optimal public-private mix [PDF]
Standard economic analysis assumes the sets of public and private goods to be exogenously given. Yet societies very often choose the public-private mix, using resources to convert seemingly private goods into ones with public goods characteristics and ...
Ravi Kanbur, Simon Clark
core