Results 91 to 100 of about 19,736,678 (402)

Circles and analogies in public health reasoning [PDF]

, 2015
The study of the fallacies has changed almost beyond recognition since Charles Hamblin called for a radical reappraisal of this area of logical inquiry in his 1970 book Fallacies.
Cummings, L
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

A Comparison of Patient Satisfaction When Using the Insured and Non-insured in Public Health Center (Puskesmas Kasihan 1) Bantul, Indonesia

, 2022
Fatma Siti Fatimah, Sumarni Sumarni, Raden Jaka Sarwadhamana, Rizka Mulyani, Putri Daru Handayani   +4 more
openalex   +2 more sources

A translational framework for public health research [PDF]

, 2009
<p><b>Background</b></p> <p>The paradigm of translational medicine that underpins frameworks such as the Cooksey report on the funding of health research does not adequately reflect the complex reality of the public health ...
A Bradford Hill, A Lyon, A Raffle, A Wakefield, B Lo, Committee of Inquiry into the Future Development of the Public Health Function, D Cooksey, D Dougherty, D Elliman, D Ogilvie, D Ogilvie, D Wanless, David Ogilvie, E Ginexi, F Cappuccio, Foresight, G Duyk, I Chalmers, J Lavis, J Lavis, J Lavis, J Tudor Hart, J Westfall, K Narayan, K Narayan, L Arai, L Bero, M Lean, M Petticrew, M Petticrew, M Petticrew, M Petticrew, M Whitehead, N Cook, N Saeed, N Sung, Nicholas J Wareham, P Alderson, P Blair, P Craig, P Craig, P Wilson, Peter Craig, R Beaglehole, R Gilbert, R Horton, R Pawson, S Cummins, S Hanney, S Hilton, S Innvær, S Kuruvilla, S Sussman, S Woolf, Sally Macintyre, Simon Griffin, T Greenhalgh, T Sheldon   +57 more
core   +3 more sources

Beyond the bedside: Clinicians as guardians of public health, medicine and science

American Journal of Emergency Medicine, 2020
A. Agarwal, M. Ranney, Bernard P. Chang
semanticscholar   +1 more source

Designing Difference in Difference Studies: Best Practices for Public Health Policy Research.

Annual Review of Public Health, 2018
The difference in difference (DID) design is a quasi-experimental research design that researchers often use to study causal relationships in public health settings where randomized controlled trials (RCTs) are infeasible or unethical.
Coady Wing, K. Simon, Ricardo A. Bello‐Gomez   +2 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Role of Game Theory in Public Health [PDF]

, 2012
Game theory, a branch of applied mathematics has been utilized by researchers in various fields including health to arrive at practical solutions to contemporary challenges.
Malhotra, VM
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source