Results 161 to 170 of about 19,736,678 (402)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida +10 morewiley +1 more sourcePeople in Public Health. Research Summary [PDF]
, 2011 Members of the public are becoming increasingly important in the delivery of public health programmes.
The work they do varies. They might give out information about a health issue or tell people about a local service.Rooke, S, South, J, Woodward, Jcore Oral diseases: a global public health challenge
The Lancet, 2019 M. Peres, L. Macpherson, R. Weyant, B. Daly, Renato Venturelli, M. Mathur, S. Listl, R. K. Celeste, C. Guarnizo-Herreño, C. Kearns, H. Benzian, P. Allison, R. Watt +12 moresemanticscholar +1 more sourceAdvancing the global public health agenda for NAFLD: a consensus statement
Nature reviews: Gastroenterology & hepatology, 2021 J. Lazarus, H. Mark, Q. Anstee, J. Arab, R. Batterham, L. Castéra, H. Cortez‐Pinto, J. Crespo, K. Cusi, M. Dirac, S. Francque, J. George, H. Hagström, T. Huang, M. Ismail, A. Kautz, S. Sarin, R. Loomba, V. Miller, P. Newsome, Michael Ninburg, P. Ocama, V. Ratziu, M. Rinella, D. Romero, M. Romero‐Gomez, J. Schattenberg, E. Tsochatzis, Luca Valenti, V. Wong, Y. Yılmaz, Z. Younossi, S. Zelber-Sagi, F. Åberg, L. Adams, M. A. Khatry, K. A. Naamani, O. Murillo, A. Allen, F. Alnaser, S. Alqahtani, K. Alswat, D. Alvaro, R. Andrade, M. Arrese, Y. Awuku, M. Ayesha, O. Baatarkhuu, S. Bakieva, R. Basu, R. Bataller, S. Bedri, E. Bosi, M. Bourlière, R. Brůha, E. Bugianesi, P. Burra, M. Buti, C. Byrne, J. Calleja, P. Carrieri, Flloyd Carter, M. C. Fernández, G. Castillo-López, Graciela E Castro-Narro, Henry Lik-Yuen Chan, W. Chan, Yoosoo Chang, M. Colombo, K. Coppell, K. Corey, A. Craxì, D. Cryer, A. Dassanayake, A. Martins, V. de Lédinghen, S. Delprato, A. Demaio, H. Desalegn, John Dillon, A. Duseja, Prabhakaran Dorairaj, M. Ekstedt, M. E. Kassas, Osama M. Elsanousi, G. Esmat, Jian-Gao Fan, N. Farpour-Lambert, R. Flisiak, Yasser M Fouad, M. Fuchs, R. Gani, L. Gerber, H. Ghazinyan, L. Gheorghe, G. Goh, H. Grønbæk, Aghayeva Gulnara, S. Hamid, Vanessa Hebditch, I. Hickman, S. Hocking, B. Hunyady, R. Idilman, V. Isakov, Mohammad H. Jamal, P. Jepsen, Natacha Jreige Iskandar, Myeong Jun Song, K. Sudhamshu, S. Kakizaki, G. Kalamitsis, F. Kanwal, J. Kao, L. Kaplan, T. Kawaguchi, Y. Khader, S. Kim, N. Kodjoh, G. Koek, K. Koike, N. Komas, Marko Korenjak, M. Kugelmas, A. Labidi, Naomi F Lange, J. Lavine, M. Lazo, N. Lee, C. R. Lesmana, Chun-Jen Liu, M. Long, P. López-Jaramillo, R. Malekzadeh, M. Mahtab, G. Marchesini, R. Marinho, S. E. M. Vázquez, L. Mateva, Charles Mbendi Nlombi, P. Mélin, I. Mikolasevic, Tamara Milovanović, C. Musso, A. Nakajima, E. Nava, A. Nersesov, D. Nikolova, S. Norris, Katja Novak, J. Oben, J. Ong, C. Onyekwere, G. Papatheodoridis, I. Paruk, K. Patel, M. P. Macedo, C. Penha-Gonçalves, M. Figueroa, W. Hofmann, S. Petta, C. D. de Oliveira, P. Puri, C. Pan, M. Rác, J. Ralston, A. Ramji, H. Razavi, M. Álvares-da-Silva, Stuart Roberts, M. Roden, Tamsin Rose, S. Rouabhia, P. Rovere-Querini, I. Rowe, S. Sadirova, R. Salupere, Tobokalova Saparbu, R. Sayegh, G. Sebastiani, Yosuke Seki, J. Selmo, A. K. Sermé, J. Shaw, Thrivikrama Shenoy, N. Sheron, O. Shibolet, Marcelo Silva, I. Skrypnyk, P. Socha, J. Soriano, C. W. Spearman, K. Sridharan, Juan José Suárez, D. Sheriff, K. Sung, M. Swain, F. Tacke, S. Taheri, S. Tan, E. Tapper, H. Yki-Järvinen, M. Thiele, I. Shawa, I. Tolmane, E. Torres, M. Trauner, S. Treeprasertsuk, A. Turcanu, J. Valantinas, M. Vesterhus, I. Waked, S. Wild, J. Willemse, R. Wong, S. Xanthakos, D. Young, Ming‐Lung Yu, Kenneth I. Zheng, Mudjat Zeybel, M. Zheng +220 moresemanticscholar +1 more sourceRecurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa +15 morewiley +1 more sourcePeroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski +17 morewiley +1 more source
