Results 181 to 190 of about 19,736,678 (402)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Reinvigorating the public health response to dementia

The Lancet Public Health, 2021
The Lancet Public Health
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Antimicrobial resistance: risk analysis methodology for the potential impact on public health of antimicrobial resistant bacteria of animal origin

, 2001
David Vose, J. F. Acar, François Anthony, A. Franklin, Richa Bhardwaj Anshu Gupta, T.J. NICHOLLS, Yutaka Tamura, Sarah K. Thompson, E. J. Threlfall, M. Van Vuuren, David G. White, Henrik Caspar Wegener, M.L. COSTARRICA   +12 more
openalex   +2 more sources

Health literacy as a public health goal: a challenge for contemporary health education and communication strategies into the 21st century

, 2000
D. Nutbeam
semanticscholar   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Childhood obesity beyond COVID-19

The Lancet Public Health, 2021
The Lancet Public Health
doaj   +1 more source

Chronic kidney disease and the global public health agenda: an international consensus

Nature Reviews Nephrology
Anna Francis, M. Harhay, Albert C. M. Ong, S. Tummalapalli, Alberto Ortiz, Agnes B. Fogo, D. Fliser, Prabir Roy-Chaudhury, Monica Fontana, M. Nangaku, Christoph Wanner, Charu Malik, A. Hradsky, Dwomoa Adu, S. Bavanandan, A. Cusumano, Laura Solá, I. Ulasi, Vivekanand Jha   +18 more
semanticscholar   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

IMPACT OF CERTAIN PUBLIC HEALTH FACTORS ON THE DURATION OF INPATIENT TREATMENT OF MI PATIENTS

, 2020
Н. О. Теренда, Аrkadii Shulhai, Y. M. Petrashyk, O. N. Lytvynova, Н. Я. ПАНЧИШИН, Н. О. СЛОБОДЯН, L. V. Lishtaba, В. Л. СМІРНОВА, Л. П. Запорожан   +8 more
openalex   +1 more source