Results 41 to 50 of about 8,780,675 (339)
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Neuroeconomics and public health [PDF]
International Journal of Integrated Care, 2010 Objective: To design an economic evaluation strategy for general health promotion projects. Method: Identification of key parameters of behavioral health from neuroeconomic studies. Results: The Frontal Power of Concentration (C) is a quadripartite executive integrator depending on four key parameters: 1) The Limbic system originating ambivalent ...
openaire +9 more sources
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Labor unions: a public health institution. [PDF]
, 2015 Using a social-ecological framework, we drew on a targeted literature review and historical and contemporary cases from the US labor movement to illustrate how unions address physical and psychosocial conditions of work and the underlying inequalities ...
Malinowski, Beth +2 more
core +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Public health careers: mapping information, informing practitioner needs [PDF]
, 2016 Public health promotion and ill health prevention is a key priority for the NHS. The public health workforce is central to achieving improved health outcomes for a diverse and changing population.
Binding, Charlene +2 more
core +1 more source
Navigating public health chemicals policy in Australia: a policy maker’s and practitioner’s guide [PDF]
, 2012 Chemicals are ubiquitous in everyday life. Environmental health practitioners rely on a complex web of regulators and policy bodies to ensure the protection of public health, yet few understand the full extent of this web.
Adam Capon, James Gillespie, Wayne Smith
core +1 more source
London Journal of Primary Care, 2014 Happy New Year for 2014. This edition's public health prose is a personal view from a public health professional in a London local authority. We will bring future messages from different public health perspectives, organisations and functions. January is the month where people are even more sheepish than usual when they bump into me as they wait on the
openaire +9 more sources