Results 51 to 60 of about 9,088,322 (356)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Public Health Impacts of Climate Change [PDF]

open access: yes, 2002
According to the Intergovernmental Panel on Climate Change (IPCC), the leading scientific institution on climate change research, atmospheric concentration of carbon dioxide, the greenhouse gas most attributed to causing climate change, has increased by ...
Lisa Damon
core  

Navigating public health chemicals policy in Australia: a policy maker’s and practitioner’s guide [PDF]

open access: yes, 2012
Chemicals are ubiquitous in everyday life. Environmental health practitioners rely on a complex web of regulators and policy bodies to ensure the protection of public health, yet few understand the full extent of this web.
Adam Capon, James Gillespie, Wayne Smith
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Will dementia hamper healthy ageing?

open access: yesThe Lancet Public Health, 2022
The Lancet Public Health
doaj   +1 more source

Public health careers: mapping information, informing practitioner needs [PDF]

open access: yes, 2016
Public health promotion and ill health prevention is a key priority for the NHS. The public health workforce is central to achieving improved health outcomes for a diverse and changing population.
Binding, Charlene   +2 more
core   +1 more source

The future of public health practice in Europe [PDF]

open access: yes, 2016
The European Public Health Association (EUPHA) identifies research, training, policy and practice as the four pillars for all its work. At a conference organised by the Association of School of Public Health in the European Region (ASPHER) in May 2016,
Azzopardi Muscat, Natasha
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

Disability—a neglected issue in public health

open access: yesThe Lancet Public Health, 2021
The Lancet Public Health
doaj   +1 more source

Global public health training in the UK: preparing for the future.

open access: yes, 2011
BACKGROUND: Many major public health issues today are not confined by national boundaries. However, the global public health workforce appears unprepared to confront the challenges posed by globalization.
Hall, Jennifer A   +2 more
core   +1 more source

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