Results 51 to 60 of about 8,780,675 (339)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Public health and landfill sites [PDF]

, 2004
Landfill management is a complex discipline, requiring very high levels of organisation, and considerable investment. Until the early 1990’s most Irish landfill sites were not managed to modern standards.
Bruen, M., Crowley, D., O'Connor, P., Staines, Anthony   +3 more
core  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Examining Training Motivations Among Public Health Workers [PDF]

, 2019
CONTEXT: As public health needs and priorities evolve, maintaining a trained public health workforce is critical to the success of public health efforts. Researchers have examined training needs in various contexts and subpopulations, but a nationally
Apathy, Nate C., Yeager, Valerie A.
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Disability—a neglected issue in public health

The Lancet Public Health, 2021
The Lancet Public Health
doaj   +1 more source

The effectiveness of public health interventions to reduce the health impact of climate change:a systematic review of systematic reviews [PDF]

, 2013
Climate change is likely to be one of the most important threats to public health in the coming years. Yet despite the large number of papers considering the health impact of climate change, few have considered what public health interventions may be of ...
A Bouchama, A Croft, AJ McMichael, BF Arnold, BR Murphy, C Baker-Austin, C Gamble, C Heintze, C Savage, CE Lawrance, D Kay, D Zmirou, DE Bowler, DJ Rogers, E Esu, EN Naumova, FC Curriero, FO ter Kuile, G Nichols, GA Romero, GH Guyatt, H Balshem, H Nakato, H Paerl, HL Risebro, HW Choi, HY Richardson, IR Lake, IR Lake, J Carmona-Fonseca, J Keiser, JC Semenza, K Ohtomo, KK Ballenger-Browning, KL Bassil, L Fewtrell, Lee Hooper, M Hashizume, M Hashizume, MA Luque Fernandez, Maha Bouzid, MK van Aalst, Monica da Silva Nunes, MS Islam, N Al-Muhandis, N Siva, P Reiter, Paul R. Hunter, PM Graves, PR Hunter, PR Hunter, PR Hunter, PR Hunter, RF Baggaley, RM Elliott, RS Kovats, RS Kovats, RS Kovats, S Gundry, S Paz, S Warshafsky, SE Hrudey, T Clasen, TE Erlanger, TP Eisele, V Abrahamson, WP Schmidt, X Wang   +67 more
core   +3 more sources

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Renewing the fight to end tuberculosis

The Lancet Public Health, 2021
The Lancet Public Health
doaj   +1 more source

Global public health training in the UK: preparing for the future.

, 2011
BACKGROUND: Many major public health issues today are not confined by national boundaries. However, the global public health workforce appears unprepared to confront the challenges posed by globalization.
Hall, Jennifer A, Lee, Andrew CK, Mandeville, Kate L   +2 more
core   +1 more source