Results 71 to 80 of about 2,036,345 (306)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Implementation costs of hospital-based computerised decision support systems: a systematic review

Implementation Science, 2023
Background The importance of accurately costing implementation strategies is increasingly recognised within the field of implementation science. However, there is a lack of methodological guidance for costing implementation, particularly within digital ...
Thomasina Donovan, Bridget Abell, Manasha Fernando, Steven M. McPhail, Hannah E. Carter   +4 more
doaj   +1 more source

Investing in America's Health 2012: A State-By-State Look at Public Health Funding and Key Health Facts [PDF]

, 2012
Examines federal and state public health funding for preventive care and state variations in disease rates, healthcare access, and other data.

core  

The UK National Health Service’s 'innovation agenda': lessons on commercialization and trust [PDF]

, 2014
The UK National Health Service (the 'NHS'), encouraged by the 2011 report Innovation Health and Wealth, Accelerating Adoption and Diffusion in the NHS, and empowered by the Health and Social Care Act 2012, is in the process of adopting a new agenda for ...
Cockbain, Julian, Sterckx, Sigrid
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Tobacco use and rates of 4As delivery for treating tobacco dependence among Albanian students. A cross-sectional study

Tobacco Induced Diseases, 2018
Background Tobacco dependence treatment in clinical settings is of prime public health importance, especially in the Albanian population, as more than 23% (41% male and 5.6% female) are daily smokers.
Enkeleint A. Mechili, Charis Girvalaki, Ela Peto, Roza Risilia, Emirjona Kicaj, Filippos Filippidis, Constantine I. Vardavas   +6 more
doaj   +1 more source

The Minimum Wage and Health: A Bay Area Analysis [PDF]

, 2014
This demonstrates that a Bay Area-wide minimum wage increase would benefit the health and well-being of nearly 1 million low-wage earners. A large body of research literature on wage, income, and health demonstrates that public policy interventions that ...

core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Healthcare use for diarrhoea and dysentery in actual and hypothetical cases, Nha Trang, Viet Nam. [PDF]

, 2004
To better understand healthcare use for diarrhoea and dysentery in Nha Trang, Viet Nam, qualitative interviews with community residents and dysentery case studies were conducted. Findings were supplemented by a quantitative survey which asked respondents
Canh, Do Gia, Clemens, John D, Genberg, Becky L, Kaljee, Linda, Minh, Truong Tan, Thiem, Vu Dinh, Tho, Le Huu, Thoa, Le Thi Kim, Trach, Dang Duc, von Seidlein, Lorenz   +9 more
core  

Discovery and Testimony of Unretained Experts: Creating a Clear and Equitable Standard to Govern Compliance With Subpoenas [PDF]

, 1987
Hearing impairment is known to be one of the most frequent sensory impairments. This condition is known to be a hidden disorder which is under recognised and under treated all around the world.
Manchaiah, Vinaya K. C., Zhao, Fei
core   +2 more sources