Results 61 to 70 of about 1,189,923 (258)
Public spending and outcomes : does governance matter? [PDF]
The authors examine the role of governance-measured by level of corruption and quality of bureaucracy-and ask how it affects the relationship between public spending and outcomes.
Rajkumar, Andrew Sunil, Swaroop, Vinaya
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Comparative life expectancy in Africa [PDF]
For health outcomes, is poverty destiny? The authors explore this question for life expectancy in Africa, where health outcomes are positively correlated with income, but where the link is far from uniform.
McCarthy, F. Desmond, Wolf, Holger
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The Lancet Global Health, 2015 AbstractBackgroundAs the Ebola epidemic and other emerging diseases have shown, global health journalism has an influential role in public health action and inaction. Practical experience is important in preparing young people in ethical and technically accurate global health reporting.
Dr. H Fong, PhD +2 more
openaire +2 more sources
Food Safety Knowledge and Practice Among Community in Sg. Pelek, Sepang, Selangor Darul Ehsan [PDF]
, 2016 Food safety is a basic requirement of food quality. It is an increasingly important public health issue to prevent and control food borne illnesses. A cross-sectional study was designed to determine level of knowledge and practice on food safety, to ...
Hamid, S. A. (Sabariah) +2 more
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Editorial: Public health promotion and medical education reform, volume II
Frontiers in Public Health, 2023 Jing Tian, Jian Chen
openaire +3 more sources
Schooling and labor market impacts of a natural policy experiment [PDF]
The authors use a nationally representative household survey to estimate returns to schooling in Venezuela from instrumental variables based on a supply-side intervention in the education market.
Patrinos, Harry Anthony +1 more
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