Results 91 to 100 of about 2,308,201 (298)

AI-driven tools for the prediction of obesity-related vascular diseases: stakeholder perspectives and challenges

open access: yesFrontiers in Public Health
IntroductionWithin the Horizon Europe-funded AI-POD (AI-based tools for the Prediction of Obesity-related vascular Diseases) project, a clinical decision support system and citizen-facing mobile health application are being developed to enable ...
Kaatje Goossens   +3 more
doaj   +1 more source

Building health research systems to achieve better health [PDF]

open access: yes, 2006
Health research systems can link knowledge generation with practical concerns to improve health and health equity. Interest in health research, and in how health research systems should best be organised, is moving up the agenda of bodies such as the ...
Gonzalez-Block, MA, Hanney, S
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

open access: yes
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana   +8 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Young people's views about the purpose and composition of research ethics committees:findings from the PEARL qualitative study [PDF]

open access: yes, 2016
BACKGROUND: Avon Longitudinal Study of Parents and Children (ALSPAC) is a birth cohort study within which the Project to Enhance ALSPAC through Record Linkage (PEARL) was established to enrich the ALSPAC resource through linkage between ALSPAC ...
Audrey, Suzanne   +4 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Governing Sustainable Food and Farming Production Futures using Integrated Risk Assessment Approaches [PDF]

open access: yes, 2006
Nanofoods, 'functional foods' and biopharming are three production futures that are strongly developing despite being characterised by significant gaps in knowledge and understanding, and a peculiar scarcity of proactive processes with which to seize ...
Gesche, Astrid, Haslberger, Alexander
core   +1 more source

School-based educational and on-site vaccination intervention among adolescents: study protocol of a cluster randomised controlled trial [PDF]

open access: yes, 2019
INTRODUCTION: Childhood vaccination programmes have been established in all Organisation for Economic Co-operation and Development (OECD) countries; however, measles, mumps and rubella (MMR) as well as diphtheria, tetanus, pertussis and polio (Tdap-IPV ...
Bethke, Norma   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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