Results 221 to 230 of about 22,822,786 (291)

Pyrolyzed Photoresist as a Continuous‐Tone Mask for Grayscale Lithography

Advanced Science, EarlyView.
True grayscale contact photolithography masks are created by pyrolysis of 3D multiphoton resist patterns. The resulting carbon masks retain micrometer‐scale patterned features while providing continuous‐tone optical transmission. This approach provides access to high‐quality grayscale lithography without requiring exotic materials or commercial mask ...
Tielyr D. Creason, Gavin C. Gee, Zachary T. Piontkowski, Toai Ton‐That, Robert Reyna, Edward R. Arata, Mason Risley, Jacob D. Boissiere, Bryan Kaehr, D. Bruce Burckel   +9 more
wiley   +1 more source

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis‐Associated Metabolic Disorders in a GPR81‐Dependent Manner

Advanced Science, EarlyView.
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng, Xiaohua Li, Shuo Li, Chungen Xing, Chun Cao   +4 more
wiley   +1 more source

Propofol Modulates Fear Memory Reconsolidation by Inhibiting D2 Receptor‐Expressing Neurons in the Medial Prefrontal Cortex

Advanced Science, EarlyView.
This study shows that propofol modulates fear‐memory reconsolidation in mice. It works by suppressing D2 receptor‐expressing neurons within the medial prefrontal cortex and their connections to the basolateral amygdala. D2‐receptor agonists reproduce this fear‐reducing effect, offering potential non‐anesthetic therapeutic strategies for trauma‐related ...
Jie Li, Yi‐Ge Guo, Xing Xu, Gui‐Lin Meng, Han Li, Liu‐Wei Chu, Xin‐Yuan Chen, Xiao‐Yun Guo, Tao Xu, Ti‐Fei Yuan, Ji Hu, Xiao‐Na Zhu   +11 more
wiley   +1 more source

Accelerating High‐Fidelity Airfoil Design via Physics‐Informed Video Diffusion Model

Advanced Science, EarlyView.
Physics‐informed video diffusion enables rapid inverse aerodynamic design by mapping target lift‐to‐drag response to airfoil geometries and full‐field flow distributions. Trained on 53 400 DNS samples, the model achieves over 90% fidelity with ∼30 s inference, while experimentally realized propeller designs demonstrate a practical pathway from ...
Yifeng Ai, Yijia Guo, Hongfu Zhang, Lei Zhou, Tiejun Huang, Weiqiu Chen, Xuhui He, Peng Guo, C. W. Lim, Lei Ma   +9 more
wiley   +1 more source

From administrative data to action: Why Ecuador needs an economic burden assessment on child maltreatment. [PDF]

Front Public Health
Quiroz-Cárdenas F, Quiroz-Cárdenas D, López-Gil JF.   +2 more
europepmc   +1 more source

RUNX1‐Mediated Hypoxic Signaling Impairs Myogenesis and Promotes Fibrosis in Myopathies

Advanced Science, EarlyView.
Myofiber overgrowth was associated with reduced blood flow and a potential hypoxic state in broiler breast muscle, accompanied by increased RUNX1 expression. Elevated RUNX1 impaired myogenic regeneration, promoted fibrosis, and disrupted the signaling niche required for efficient muscle repair, contributing to pathological degeneration in Wooden Breast
Liang Zhao, Taijiang Hou, Lin Zhang, Feng Gao, Tong Xing   +4 more
wiley   +1 more source

Unequal spending, unequal care: Race and ethnicity and their interactions with clinical and socioeconomic factors in health care expenditures among older adults with cardiovascular disease. [PDF]

J Manag Care Spec Pharm
Zakeri M, Arefin P, Sansgiry SS.
europepmc   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Out-of-pocket health expenditures as a barrier to healthcare access, financial protection, and progress toward universal health coverage: a narrative review from Somalia. [PDF]

Front Public Health
Bashir SG, Abdullahi Khalif I, Abdi MS, Burhan Abdullahi Y.   +3 more
europepmc   +1 more source