Results 161 to 170 of about 24,112,168 (322)
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
Health Impact Assessment contributing to Healthy Public Policy
, 2009 Published by Public Health, April 2009 IPH recently coordinated and was guest editor for a minisymposium on Health Impact Assessment for the journal, Public Health.
Institute of Public Health in Ireland
core +1 more source
Polymer‐Grafted Cu(II) Metal–Organic Polyhedra as Scalable, Melt‐Processable Porous Materials
Advanced Science, EarlyView.The use of a direct synthetic route to obtain polymer‐grafted Cu(II)‐based metal–organic polyhedra gives rise to a low‐cost and scalable cage. This material combines low‐temperature melting, achieving phase changes while preserving cage integrity, and high CO2 uptake exceeding 0.6 mmol g−1.
Alba Cortés‐Martínez +6 more
wiley +1 more source
Public and Private Expenditures on Health in a Growth Model [PDF]
This paper introduces endogenous longevity in an otherwise standard overlapping generations model with capital. In the model, a young agent may increase the length of her old age by incurring investments in health funded from her wage income.
Bhattacharya, Joydeep, Qiao, Xue
core
VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
Advanced Science, EarlyView.Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan +10 more
wiley +1 more source
Role of Public Expenditures and Macroeconomic Uncertainty in Determining Private Investment in Large Scale Manufacturing Sector of Pakistan [PDF]
Considering the importance of large scale manufacturing sector in Pakistan economy we analysed investment behavior of private sector in large scale manufacturing.
Qayyum, Abdul, Ahmad, Imtiaz
core
Advanced Science, EarlyView.Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li +17 more
wiley +1 more source
Advanced Science, EarlyView.Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng +13 more
wiley +1 more source
Health Expenditures Under the HIPC Debt Initiative [PDF]
One of the goals of the Heavily Indebted Poor Countries (HIPC) debt initiative is to provide additional resources for basic health care to the population of eligible developing countries.
Ralf Hepp
core