Results 61 to 70 of about 1,790,017 (349)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

A Disaster Response and Management Competency Mapping of Community Nurses in China

Iranian Journal of Public Health, 2013
Background: It is widely accepted in many parts of the world that community nurses are of vital importance in various phases of disaster response and management.
Yu Luo, Ling Liu, Wen-Quan Huang, Ya-Na Yang, Jie Deng, Chun-Hong Yin, Hui Ren, Xian-Yuan Wang   +7 more
doaj   +2 more sources

Validation of the PHNs precepting experiential learning causal model for preceptors of novice public health nurses in Japan

Nursing Open, 2020
Aims The purpose of this study was to analyse the relationship among public health nurse (PHN) precepting experiential learning (PHN‐PEL) and the outcomes.
Taeko Shimazu
doaj   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

Nurse–Physician Communication in Patient Care and Associated Factors in Public Hospitals of Harari Regional State and Dire-Dawa City Administration, Eastern Ethiopia: A Multicenter-Mixed Methods Study

Journal of Multidisciplinary Healthcare, 2021
Mehammedamin Jemal,1 Mohammed Abdurke Kure,2 Tesfaye Gobena,3 Biftu Geda2 1Department of Nursing, Hiwot Fana Specialized University Hospital, Haramaya University, Harar, Ethiopia; 2School of Nursing and Midwifery, College of Health and Medical Sciences ...
Jemal M, Kure MA, Gobena T, Geda B
doaj  

The Role of African Nurse Diaspora in Addressing Public Health Priorities in Africa

Global Qualitative Nursing Research, 2021
African countries experience many complex public health challenges that, to tackle, require coordinated, multi-stakeholder, collaborative partnerships at local and global levels.
Mabel Ezeonwu
doaj   +1 more source

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
wiley   +1 more source

Nurse-Family Partnership and Geography: An Intersectional Perspective

Global Qualitative Nursing Research, 2020
Nurse-Family Partnership is a targeted public health intervention program designed to improve child and maternal health through nurse home visiting. In the context of a process evaluation, we posed the question: “In what ways do Canadian public health ...
Karen A. Campbell, Karen MacKinnon, Maureen Dobbins, Susan M. Jack,   +4 more
doaj   +1 more source

The Organoleptic Test Formulations Snakehead Fish Flour Based Functional Cookies as An Alternative Snack For Stunting Toddlers

International Journal of Agricultural Sciences, 2022
The substitution of Snakehead fish flour to make the cookies have the function of increasing nutrient. This study analyzes the effects of Snakehead fish flour on the sensory characteristics of cookies.
Helmizar Helmizar, Putri Aulia Arza, Restu Sakinah, Susmiati Susmiati   +3 more
doaj   +1 more source