Results 81 to 90 of about 5,706,223 (363)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Association Between Allostatic Load and Incident Colorectal Cancer—A Prospective Study in a Multiethnic Asian Population

Cancer Medicine
Background Allostatic load (AL) reflects the cumulative physiological burden of chronic stress across cardiovascular, metabolic, immune, and renal systems. While AL has been implicated in cancer development, evidence in Asian populations remains limited.
Su Hyun Park, Isaiah Soh, Peh Joo Ho, Miao Hui, Charlie Guan Yi Lim, Xueling Sim, Adeline Seow   +6 more
doaj   +1 more source

Drivers of hospital expenditure and length of stay in an academic medical centre: a retrospective cross-sectional study

BMC Health Services Research, 2019
Background As healthcare expenditure and utilization continue to rise, understanding key drivers of hospital expenditure and utilization is crucial in policy development and service planning.
Nabilah Rahman, Sheryl Hui-Xian Ng, Sravan Ramachandran, Debby D. Wang, Srinath Sridharan, Chuen Seng Tan, Astrid Khoo, Xin Quan Tan   +7 more
doaj   +1 more source

Current Problems in the Financing of the Czech Public Health System [PDF]

The reform of the Czech public health system started in 1991. The main goals were the liquidation of the state's monopoly on health services, the creation of non-state health care that would include private facilities, and the introduction of multi ...
Vera Uldrichova
core  

Acceptance of Health Information System for Public Health Centre in North Borneo, Indonesia [PDF]

, 2018
This study sought the factor associated with own acceptance of HIS for PHC by using the modification of Technology Acceptance Model (TAM) in the Sebengkok PHC, Central Tarakan Subdistrict, Tarakan City, North Borneo, Indonesia. A cross-sectional approach
Kusumawati, N. I. (Nurul), Sulistyawati, S. (Sulistyawati)   +1 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Impact of recent decisions and discussions on the Brazilian Public Health System financing

, 2021
Fabíola Sulpino Vieira
openalex   +1 more source

Public Health in the Health Care System

Gubernaculum et Administratio, 2023
Public health encompasses a wide range of activities related to almost all aspects of the society’s health. Public health influences the shape of social and health policy of the state, and cooperates with all socio-economic sectors and social organizations.
openaire   +1 more source

Ex Post Welfare under Alternative Health Care Systems [PDF]

This paper studies the implications of a societal aversion to inequality for the optimal design of a public health care system. Inequality aversion is introduced by postulating a strictly concave ex post social welfare function.
John Leach
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source