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This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong +8 more
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ABSTRACT Hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited efficacy of conventional treatments like surgery, radiofrequency ablation (RFA), and transarterial embolization (TAE). Here, we develop an innovative TAE and immunothermal therapy strategy based on smartly assembled near‐micron layered double hydroxide ...
Qitao Hu +12 more
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Programmable RNA N6,2´‐O‐Dimethyladenosine Editing
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li +9 more
wiley +1 more source
Modeling Social Network Influences on Oral Health Outcomes among Women Living in Public Housing. [PDF]
Heaton B, Bond JC, Bae J, Pullen E.
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From public housing to public–private housing
2022Lawrence J. Vale, Yonah Freemark
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Public Schools, Public Housing: The Education of Children Living in Public Housing
Urban Affairs Review, 2010In the United States, public housing developments are predominantly located in neighborhoods with low median incomes, high rates of poverty and disproportionate concentrations of minorities. While research consistently shows that public housing developments are located in economically and socially disadvantaged neighborhoods, we know little about the ...
Amy Ellen Schwartz +3 more
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From Public Housing to Public-Private Housing
Journal of the American Planning Association, 2012Lawrence J. Vale, Yonah Freemark
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