Results 101 to 110 of about 22,684,611 (251)

PRISM: Personalizing Reporting With Intelligent Summarization Through Multiple Frames

IEEE Access
As the challenges of information overload and selection fatigue in the digital news environment persist, natural language processing techniques have become increasingly critical for personalizing information delivery. This paper introduces a novel, frame-
Kyohoon Jin, Sejin Paik, Jungmin Yun, Soojin Jang, Youngbin Kim   +4 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Oskaloosa Public Library Scene, circa 1940; Mahaska County; Iowa

, 1940
This is an image capturing head librarian, Elizabeth Michener, reading to a group of children at the Oskaloosa Public Library, circa 1940. Ms. Michener worked as head librarian at the public library for several decades, demonstrating her charisma and ...
Oskaloosa Public Library
core   +1 more source

Associations of early-adulthood adiposity with breast parenchymal tissue complexity within premenopausal women

Breast Cancer Research
Background Early-adulthood adiposity is associated with breast cancer risk. This study aims to evaluate the associations of early-adulthood adiposity with an emerging biomarker of breast cancer risk, breast parenchymal complexity, within premenopausal ...
Sneha Das Gupta, Kayla Getz, Juanita Hernandez Lopez, Debbie L. Bennett, Adetunji T. Toriola, Aimilia Gastounioti   +5 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Masculinity in the public image of physics and mathematics: a new model comparing Japan and England. [PDF]

Public Underst Sci, 2021
Ikkatai Y, Inoue A, Minamizaki A, Kano K, McKay E, Yokoyama HM.   +5 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

[Self-image and public image of nursing: a quantitative and qualitative cross-sectional study]. [PDF]

Pravent Gesundh, 2023
Julier-Abgottspon E, Brunner-Pfaffen S, Eissler C.   +2 more
europepmc   +1 more source