Results 71 to 80 of about 22,684,611 (251)

Dover Public Library exterior

, 1967
This negative shows the front exterior of the old Dover Public Library at 45 South State ...
Department of State, Delaware Public Archives
core   +2 more sources

SEM Image

, 2017
This photograph originally appeared in the 2017 Research student photography and image competition held to celebrate National Science Week (18 August - 8 September 2017).
Azam Dolatshah
core   +1 more source

FDWD-Net: Feature-Decoupled and Window-Differentiated Network for Remote Sensing Image Super-Resolution

Remote Sensing
Super-resolution reconstruction of remote sensing images has significant application value in fields such as smart cities, land monitoring, and traffic management.
Yinghua Li, Ting Fan, Yining Zhang, Xiwen Yang, Jian Xu, Kaichen Chi   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The Groundbreaking Ceremony for the New Building

, 1994
A groundbreaking ceremony was held on September 11, 1994 and construction began on November 9, 1994. The building officially opened to the public on February 16, 1996.
Indian Prairie Public Library
core  

CPINet: Towards A Novel Cross-Polarimetric Interaction Network for Dual-Polarized SAR Ship Classification

Remote Sensing
With the rapid development of the modern world, it is imperative to achieve effective and efficient monitoring for territories of interest, especially for the broad ocean area. For surveillance of ship targets at sea, a common and powerful approach is to
Jinglu He, Ruiting Sun, Yingying Kong, Wenlong Chang, Chenglu Sun, Gaige Chen, Yinghua Li, Zhe Meng, Fuping Wang   +8 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

NORMS, SELF-SANCTIONING, AND CONTRIBUTIONS TO THE PUBLIC GOOD [PDF]

The relationship between norms, self-sanctioning, and people’s decisions about contributing to public goods is complex and often misunderstood in the public goods literature.
Haab, Timothy C., Interis, Matthew G.
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source