Results 121 to 130 of about 43,302,612 (311)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Public Health Information Network Messaging System acronyms and glossary

open access: yes
Version: 1.0.3, March 27, 2008The Public Health Information Network Messaging System (PHINMS) is a secure and reliable data transport system built to open standards.

core  

Challenges and Strategies in Building Public Information Openness

open access: yesEkspresi dan Persepsi: Jurnal Ilmu Komunikasi
Despite the importance of information transparency, many institutions face underappreciated challenges when implementing transparent practices. This study seeks to systematically identify barriers to information openness and proposes actionable ...
Yudie Aprianto, Olumayowa Adeleke Idowu
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Voters response to public information disclosure policies in the local head election of Ciamis Regency 2024

open access: yesOtoritas: Jurnal Ilmu Pemerintahan
The lack of political education for the people of Ciamis Regency in local head elections has an impact on the lack of voter information on local head candidates, so that political behavior is based on assumptions and non-rational factors.
Kiki Endah   +2 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

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