Results 121 to 130 of about 1,300,731 (292)
Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics
Advanced Science, EarlyView.Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan +12 more
wiley +1 more source
Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework
Advanced Science, EarlyView.PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen +11 more
wiley +1 more source
Investigating the financialization of water infrastructure in China: A public policy perspective
Water PolicyInsufficient funding for water infrastructure has become a notable challenge for China and other developing countries. In light of marketization and globalization, financialization has emerged as a potential avenue to address the financial difficulties ...
Zhen Wang +4 more
doaj +1 more source
what is missing between agricultural growth and infrastructure development ? cases of coffee and dairy in Africa [PDF]
Although it is commonly believed that aggregate economic growth must be associated with public infrastructure stocks, the possible infrastructure needs and effects are different from industry to industry. The agriculture sector is typical.
Iimi, Atsushi, Smith, James Wilson
core
Advanced Science, EarlyView.SpaBatch is an end‐to‐end multi‐slice spatial transcriptomics data integration framework. It simultaneously performs embedding learning, spatial feature denoising and reconstruction, batch effect correction, and spatial domain optimization, effectively correcting batch effects and achieving accurate 3D spatial domain identification.
Jinyun Niu +5 more
wiley +1 more source
Journal of Informatics and Web EngineeringIn this paper, we present the implementation of the Cha-Cheon Identity-Based Signature (IBS) scheme to enhance secure data transfer in cloud computing environments.
Paul Osinuga +2 more
doaj +1 more source
Advanced Science, EarlyView.An enhanced one‐pot, helicase‐assisted recombinase polymerase amplification (hRPA)‐combined, dual‐CRISPR/uAsCas12a assay is developed and lyophilized on a 3D‐printed microfluidic disc to achieve field‐deployable multiplex bacteria detection. Abstract One‐pot CRISPR‐based detection combining recombinase polymerase amplification (RPA) enables rapid and ...
Yuqing Shen, Bo Lu, Biao Ma, Xiong Ding
wiley +1 more source
Photopolymerized Mixed Matrix Membranes for Liquid Organic Hydrogen Carrier Separation
Advanced Science, EarlyView.Photopolymerized membranes with high metal organic framework (MOF)/Pd activated carbon loading enable selective separation of hydrogen‐rich/lean liquid organic hydrogen carriers (LOHCs) under mild operational conditions. The employed fabrication approach yields stratified, multilayer structures with enhanced aromatic/aliphatic (toluene ...
Abdollah Khosravanian +8 more
wiley +1 more source
Incorporating Trust in Public Key Infrastructure Certificates
, 2017 P. P. Rahoof +2 more
openalex +1 more source
Parabiosis, Assembloids, Organoids (PAO)
Advanced Science, EarlyView.This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong +5 more
wiley +1 more source