Results 41 to 50 of about 1,346,642 (294)
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Securing Information Systems in an Uncertain World Enterprise Level Security (Invited Paper) [PDF]
Journal of Systemics, Cybernetics and Informatics, 2016 Increasing threat intrusions to enterprise computing systems have led to a formulation of guarded enterprise systems. The approach was to put in place steel gates and prevent hostile entities from entering the enterprise domain.
William R. Simpson
doaj
Veritaa: A distributed public key infrastructure with signature store [PDF]
, 2021 Jakob Schaerer +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Caution Ahead: Overdue Investments in New York's Aging Infrastructure [PDF]
, 2014 While Superstorm Sandy focused much-needed attention on key pieces of New York City's infrastructure, the city faces a number of other infrastructure vulnerabilities that have little to do with storm-preparedness -- from aging water mains and ...
Adam Forman
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
A Blockchain-Based Decentralized Public Key Infrastructure Using the Web of Trust
Journal of Cybersecurity and PrivacyInternet applications rely on Secure Socket Layer (SSL)/Transport Security Layer (TSL) certifications to establish secure communication. However, the centralized nature of certificate authorities (CAs) poses a risk, as malicious third parties could ...
Ratna Halder +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
The use of maxLength in the RPKI [PDF]
, 2018 This document recommends that operators avoid using the maxLength attribute when issuing Route Origin Authorizations (ROAs) in the Resource Public Key Infrastructure (RPKI). These recommendations complement those in [RFC7115].https://datatracker.ietf.org/
Gilad, Yossi +4 more
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source