Results 171 to 180 of about 379,591 (337)

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

open access: yesAdvanced Science, EarlyView.
Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen   +9 more
wiley   +1 more source

Bristol Public Library

open access: yes, 2006
[ES] El mundo que encierra mundos de Juan Eslava ...
openaire   +2 more sources

Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population

open access: yesAdvanced Science, EarlyView.
This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen   +16 more
wiley   +1 more source

LibEvolutionEval: A Benchmark and Study for Version-Specific Code Generation [PDF]

open access: yesProceedings of the 2025 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Albuquerque, New Mexico, USA, April 2-7, 2025
Recent advancements in code completion models have primarily focused on local file contexts. However, these studies do not fully capture the complexity of real-world software development, which often requires the use of rapidly-evolving public libraries.
arxiv  

Structural Diversity of Mitochondria in the Neuromuscular System across Development Revealed by 3D Electron Microscopy

open access: yesAdvanced Science, EarlyView.
Mitochondria across the entire neuromuscular system have been comprehensively reconstructed at different developmental stages using 3D electron microscopy. Fundamental structural principles related to synaptic function are preserved across development, and these morphologies are adapted to ensure effective neural circuit function.
J. Alexander Bae   +9 more
wiley   +1 more source

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

open access: yesAdvanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan   +16 more
wiley   +1 more source

Home - About - Disclaimer - Privacy