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Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

open access: yesAdvanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu   +8 more
wiley   +1 more source

Investigating the Impact of Online Abortion Myths on Health Care Providers and Advocates: Interview Study. [PDF]

open access: yesJMIR Public Health Surveill
Moran RE   +7 more
europepmc   +1 more source

Social media, addiction, and youth mental health. [PDF]

open access: yesLancet Reg Health Am
Mays D   +4 more
europepmc   +1 more source

Physical education across international media (2018-2024): dominant narratives and global patterns of portrayal. [PDF]

open access: yesFront Sports Act Living
Hyndman B   +7 more
europepmc   +1 more source
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