Results 91 to 100 of about 988,014 (312)

On public policies to fight food insecurity: a current and necessary reflection from the Ubuntu perspective

, 2023
Edna Raquel Hogemann, Benedito Antônio Lopes da Fonseca, Oswaldo Pereira de Lima   +2 more
openalex   +2 more sources

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Public health partner authorities—How a health in all policies approach could support the development of a wellbeing economy [PDF]

, 2023
A Porcelli, Katina D’Onise, Katherine Pontifex   +2 more
openalex   +1 more source

An Enzyme‐Like Catalyzed Nanosheets for Redox Stress Oscillation Therapy Against Bacterial Infections

Advanced Science, EarlyView.
Bacterial biofilms form a physicochemical barrier. Their dense network structure and redox homeostasis confer high resistance to antimicrobial treatments and immune‐mediated killing and clearance. In this study, SnSe nanosheets with enzyme‐like properties and piezoelectric catalysis can oscillate to regulate bacterial redox homeostasis and improve the ...
Min Ge, Zhao Guo, Zhiming Zhang, Lanlu Lu, Zesong Ruan, Tingwang Shi, Yunfeng Chen, Ju Huang, Chaoliang Tan, Han Lin   +9 more
wiley   +1 more source

Public Policy Instruments Selected in Policy Implementation Prostitution Prevention and Revocation in Surabaya City

, 2021
Nurul Umi Ati
openalex   +2 more sources

Connected Education Innovation Program: a new national policy for the use of digital technologies in public schools in Amazon [PDF]

, 2022
José Augusto de Melo Neto, Selma Suely Baçal de Oliveira   +1 more
openalex   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Childhood intra- and extra-familial maltreatment and later-life trajectories of depressive symptoms: evidence from China

BMC Geriatrics
Background Both late-life depression and childhood maltreatment have become major global public health issues, given their prevalence and social-economic and health consequences.
Tingshuai Ge, Yixiao Liu, Qing Han, Xinfeng Cheng, Quanbao Jiang   +4 more
doaj   +1 more source

Public Policy (Orde public)

European Property Law Journal, 2020
openaire   +2 more sources