Results 101 to 110 of about 2,740,550 (314)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Alaska Trial Court Caseload FY 2007–2018 [PDF]

open access: yes, 2019
Underlying data is available in both Excel and PDF format. (Download below.)This fact sheet presents data on criminal case filings in Alaska trial courts for fiscal years 2007–2018.
Kisarauskas, Yevgenii
core  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Property Taxation in the People\u27s Republic of China [PDF]

open access: yes, 2014
A property tax is a general tax imposed on all property owners based on the value of their properties. Property taxation is common throughout the world due to its numerous advantages. It is regarded as a steady source of local government revenue.
Asian Development Bank
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Capitalization of the Public Domain. Public Concession Contract

open access: yesJournal of Danubian Studies and Research, 2020
The field of public acquisition has a special relevance whose core consists in the involvement of public capital for their realization. Public acquisition enjoys an importance both at national and European level, being a stage that precedes and ...
Maria-Cristiana Ieremie
doaj  

REVISITING COMMONS – ARE COMMON PROPERTY REGIMES IRRATIONAL? [PDF]

open access: yes
This paper revisits the debate about communal management of natural resources and brings together various issues confronting it. Much of the criticism against common property regimes stems from an incorrect modeling of a common property situation, and ...
Hasan, Lubna
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Comparing safety climate in infrastructure and building projects in Indonesia

open access: yesMATEC Web of Conferences, 2019
Despite the rapid growth of the Indonesian construction industry and its significance to the national economy, health and safety in the industry remains poor.
Sunindijo Riza Yosia   +6 more
doaj   +1 more source

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