Results 71 to 80 of about 14,169,687 (279)

Epistemic Democracy and the Truth Connection [PDF]

Public Reason
If political decision-making aims at getting a particular result, like identifying just laws or policies that promote the common good, then political institutions can also be evaluated in terms of how often they achieve these results.
Robert Weston Siscoe
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Introduction [PDF]

Public Reason
Introduction
Jakub Szczepanski
doaj  

Vaccine Passports and Political Legitimacy: A Public Reason Framework for Policymakers. [PDF]

Ethical Theory Moral Pract, 2023
Barnhill A, Bonotti M, Susser D.
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The Significance of Deep Disagreements on Justice, Values, and Morals for Political Epistemology [PDF]

Public Reason
Political epistemology asks whether there is knowledge about values, the good, the just, and the morally right that could be applied to political issues. Debates on such questions go back to the ancient Greeks. While Protagoras claims that no moral facts
Manuel Knoll
doaj  

 Public Reason in a Pandemic: John Rawls on Truth in the Age of COVID-19. [PDF]

Philosophia (Ramat Gan), 2022
Warner CH.
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

On Public Reason [PDF]

, 1994
Since the publication of A Theory of Justice in 1971, John Rawls has refined, qualified, and enriched his political philosophy, responding generously and with patient analytical care to difficulties posed by critics.
Greenawalt, Kent
core   +3 more sources