Results 111 to 120 of about 37,200 (259)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Weekend Warrior and Other Leisure-Time Physical Activity Patterns in Relation to Positive Self-Rated Health: Racial Differences Among Brazilian University Students. [PDF]

Int J Environ Res Public Health
Sousa TF, Pereira KM, Conceição YDS, Matos CDS, Santana DP, Santos AJ, Maciel CL, Borges GF.   +7 more
europepmc   +1 more source

Adversarial Erasing Enhanced Multiple Instance Learning (siMILe): Discriminative Identification of Oligomeric Protein Structures in Single Molecule Localization Microscopy

Advanced Intelligent Systems, EarlyView.
Hallgrimson et al. introduce a machine learning algorithm, siMILe, that takes features of single‐molecule localization microscopy localization clusters (e.g., size and sphericity) and finds the clusters that are associated with certain cell conditions (such as differential protein expression or drug treatment).
Christian Hallgrimson, Y. Lydia Li, Claire A. Shou, Ben Cardoen, John Lim, Timothy H. Wong, Ismail M. Khater, Ivan Robert Nabi, Ghassan Hamarneh   +8 more
wiley   +1 more source

Retinal Vessel Segmentation: A Comprehensive Review From Classical Methods to Deep Learning Advances (1982–2025)

Advanced Intelligent Systems, EarlyView.
Four decades of retinal vessel segmentation research (1982–2025) are synthesized, spanning classical image processing, machine learning, and deep learning paradigms. A meta‐analysis of 428 studies establishes a unified taxonomy and highlights performance trends, generalization capabilities, and clinical relevance.
Avinash Bansal, Jan Kubíček, Jana Bahrová, Alice Varyšová, Martin Augustýnek, Marek Penhaker, Juraj Timkovič   +6 more
wiley   +1 more source

Reporting of structural population assumptions in prevalence-based studies of animal feeding operations and community health. [PDF]

Front Public Health
Martinez BAF, Sargeant JM, Totton SC, Wang C, O'Connor AM.   +4 more
europepmc   +1 more source

ParamNet: A Physics‐Guided Deep Learning Framework for Intelligent Self‐Inversion of Vacuum Optical Levitation Systems

Advanced Intelligent Systems, EarlyView.
A physics‐guided deep learning framework, ParamNet, is introduced for the intelligent self‐inversion of vacuum optical tweezers. By fuzing dual‐branch time–frequency features with physical dynamical constraints, it achieves high‐accuracy calibration of trap parameters from short‐window, low‐frequency trajectories, outperforming traditional methods ...
Qi Zheng, Wenfeng Fan, Feng Li, Jian Wu, Wei Quan   +4 more
wiley   +1 more source

Changes in alcohol consumption and the risk of postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort. [PDF]

Eur J Nutr
Antoniussen CS, Ibsen DB, Olsen A, Overvad K, Vasson F, Severi G, Dragic D, Truong T, Fortner RT, Le Cornet C, Schulze MB, Di Girolamo C, Pala V, Doccioli C, Agudo A, Guevara M, Tin Tin S, Jackson IG, Gunter MJ, Dossus L, Ferrari P, Dahm CC.   +21 more
europepmc   +1 more source

AI‐Assisted IoT‐Enabled ECG Monitoring: Integrating Foundational and Generative AI Tools for Sustainable Smart Healthcare—Recent Trends

AI &Innovation, EarlyView.
ABSTRACT The rapid evolution of the Internet of Things (IoT) has significantly advanced the field of electrocardiogram (ECG) monitoring, enabling real‐time, remote, and patient‐centric cardiac care. This paper presents a comprehensive survey of AI assisted IoT‐based ECG monitoring systems, focusing on the integration of emerging technologies such as ...
Amrita Choudhury, Kandarpa Kumar Sarma, Lachit Dutta   +2 more
wiley   +1 more source

Individual and environmental determinants of body mass index trajectories: results from a longitudinal study in Southern Sweden. [PDF]

BMC Public Health
Rebouillat P, Mattisson K, Gefenaite G, Östergren PO, Nilsson PM, Björk J.   +5 more
europepmc   +1 more source