Results 41 to 50 of about 13,711,001 (247)

Assessing Strengths and Limitations of Magnetoencephalography Source Imaging With Intracerebral EEG

Advanced Science, EarlyView.
Simultaneous MEG and stereotactic EEG (SEEG) recordings provide a direct validation framework for MEG source imaging in focal epilepsy. Virtual SEEG signals derived from MEG reconstructions reveal significant agreement with intracranial measures of spike localization, resting‐state oscillations, and functional connectivity, while also identifying ...
Jawata Afnan, Maria Fratello, Francesca Bonini, Samuel Medina Villalon, Zhengchen Cai, Jean‐Marc Lina, Jean‐Michel Badier, Fabrice Bartolomei, Jean Gotman, Christian G. Bénar, Christophe Grova   +10 more
wiley   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Factors influencing PrEP adoption in sexual health clinics within Ontario’s public health system: a qualitative study using the Consolidated Framework for Implementation Research (CFIR)

Frontiers in Public Health
IntroductionHIV pre-exposure prophylaxis (PrEP) utilization in Ontario is concentrated in two large urban centers, resulting in geographic and structural inequities in access. Little is known about adoption in Public Health Sexual Health Clinics (PHSHCs)
Emma Nagy, Beatriz Alvarado, Carmela Rapino, Carmela Rapino, Oluwatoyosi Kuforiji, Nicholas Cofie, Bradley Stoner, Nancy Dalgarno, Pilar Camargo-Plazas, T. Hugh Guan, Jorge Martinez-Cajas   +10 more
doaj   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

The Challenge of Globalization to American Public Law Scholarship

, 2001
American public law scholarship views law as a purposive instrument for the achievement of democratic purposes. It has analyzed how this instrument can best be employed within the historical context of the legal institutions and traditions of particular ...
Post, Robert C
core   +1 more source

Public Choice and the Future of Public-Choice-Influenced Legal Scholarship [PDF]

, 1997
By many yardsticks, public choice is the single most successful transplant from the world of economics to legal scholarship., As with other law-and-economics scholarship, critics have attacked its assumptions, its methodology, and its conclusions.
Skeel, Jr., David A.
core   +1 more source

Freedom of Religion in Communities of Legal Scholarship: A Christian Perspective [PDF]

Australian Journal of Law & Religion
Legal scholarship (as with a range of other disciplines) inextricably relates to its author’s foundational beliefs (comprised of, for example, ontological and cosmological views, moral convictions, and the like).
Shaun de Freitas
doaj   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

PROFISSÃO ACADÊMICA E SCHOLARSHIP DA DOCÊNCIA UNIVERSITÁRIA: OS MÚLTIPLOS PAPÉIS DO PROFESOR UNIVERSITÁRIO [PDF]

, 2010
O reconhecimento da qualidade do trabalho docente em atividades não diretamente relacionadas à pesquisa e a crescente exigência da sociedade por uma contribuição mais relevante da universidade para a solução de seus problemas prementes levaram à busca de
SANTOS FILHO, JOSÉ CAMILO DOS
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