Results 51 to 60 of about 24,977 (259)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Politics-Administration Interface and Sustenance of Public Service Ethos in South-West Nigeria

Africa’s Public Service Delivery & Performance Review, 2016
This work examined politics-administration interface and the sustenance of public service ethos in Southwest Nigeria. Public servants and political functionaries in Southwest Nigeria are constantly in a struggle to fix each other in their pre-conceived ...
Salami Issa Afegbua
doaj   +1 more source

Ensuring the quality of professional activity of civil servants

Aspekti Publìčnogo Upravlìnnâ, 2020
The professional activity of civil servants plays a significant role in streamlining and normalizing the processes of social and economic life of the country.
Svitlana Hanotska
doaj   +1 more source

The deliberative public servants: The roles of public servants in citizens’ assemblies

, 2023
Forseveral decades, numerous citizens' assemblies involvingcitizens in public decision-makinghavebeen multiplying at all levels of power.This development of a more participatory,deliberative or collaborative democracy implies the transformation of public administrationsand public servants.Various studies show that civil servants are keya ctors in the ...
Bottin, Jehan, Mazeaud, Alice
openaire   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

"QUALITY" OF STANDARDIZATION OF ADMISSION TO MUNICIPAL PASSENGER TRANSPORTATION AS A CORRUPTION RISK "FILTER" IN ACTIVITY OF PUBLIC SERVANTS

Baltic Journal of Economic Studies, 2020
Relevance. In terms of revising the provisions of legal regulation of relations in the field of transport with the borrowing of competitive principles of the European institutes to ensure the integration of transport into European and world transport ...
Tatiana Kolomoiets, Oleksii Makarenkov, Georgiy Samoylenko   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Representation: Public Servants in Public

, 2020
In scholarship on public servants, they are represented in various ways across disciplines as we can see from the various contributions to this handbook. This section of the book considers how public servants are represented in broader public culture. A key question addressed is whether we want our public servants to be ideal heroes or whether we need ...
openaire   +2 more sources