Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin +20 more
wiley +1 more source
Sex and rank in public service hierarchies: Rank distribution in Ghana's health and security services. [PDF]
Norman ID, Kpeglo ED, Nadarajah S.
europepmc +1 more source
Transactions of the thirty-ninth annual conference of state and territorial health officers with the United States Public Health Service, April 29, 1941 and May 2, 1941 [PDF]
The Thirty-Ninth Annual Conference of State and Territorial Health Officers with the Public Health Service, held in the Auditorium, U.S. Public Health Service Building, Washington, D.C., was called to order at nine-forty o'clock a.m.
core
Machine Learning for Green Solvents: Assessment, Selection and Substitution
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta +4 more
wiley +1 more source
The influence of responsible leadership on nurse's career calling: a moderated mediation model of public service motivation and moral identity. [PDF]
Chen A, Ruan W.
europepmc +1 more source
Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez +16 more
wiley +1 more source
Accessibility evaluation of public service facilities in affordable housing communities in Hangzhou, China. [PDF]
Wang J, Zhou J, Fu X.
europepmc +1 more source
Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad +12 more
wiley +1 more source
Digitization of hospital administration and public service reform: integration of technology and humanistic values. [PDF]
Utami EW +6 more
europepmc +1 more source

