Results 251 to 260 of about 1,152,837 (318)

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

The Government Built It, and the Private Sector Came: For-Profit Health Care, Government Support, and the Road from Public Service to Private Equity. [PDF]

Am J Law Med
Rosoff AJ, Field RI, Orlando AW.
europepmc   +1 more source

Assessment of the Quality of Public Data Reporting by Nonprofit Social Service Agencies Receiving Funding from the Lexington-Fayette Urban County Government in FY 2013

, 2014
Yuanyuan Song
openalex   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

Practitioners' perspectives on unintended effects of illicit drug use prevention public service announcements in Australia. [PDF]

Health Promot Int
Munro K, Bogomolova S, Simmonds L.
europepmc   +1 more source

Dumbbell‐Structured Plasmonic‐Enhanced Optical Nanoprobes Boosting Photo‐Magnetic‐Acoustic Multimodal Imaging‐Guided Photodynamic‐Photothermal Synergistic Treatment and Immunogenic Death in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study reports a novel rationally‐designed optical nanoprobe based on dumbbell‐shaped mesoporous silica‐coated gold nanorods, loaded with rare‐earth oxides, photosensitizers, and tumor‐targeted peptides, enabling plasmonic‐enhanced multimodal imaging and PTT‐PDT synergy.
Baikang Zhuang, Yubiao Yang, Wen Han, Yi Tang, Chengxin Yao, Fuli Zhao, Wenxiao Fang, Jinjie Li, Xiaolan Huo, Yiqian An, Yuanzhi Shao, Botao Gao, Jinchang Yin   +12 more
wiley   +1 more source

Barriers to seeking consultation at public service and medical facilities among pregnant and postpartum women in Japan: a cross-sectional study. [PDF]

PeerJ
Okawa S, Seino K, Iso H, Tabuchi T.
europepmc   +1 more source

Information technology skills for the South African public service

, 2010
Liza Ceciel van Jaarsveldt, Liza Ceciel
openalex   +1 more source

Orthogonal Design of Competing Deprotonation Process in Cation‐Mediated Ni(OH)2 for Achieving Industrial Level Biomass Electrooxidation

Advanced Science, EarlyView.
A Cu‐mediated Ni(OH)2 catalyst with orthogonal activity by precise valence engineering simultaneously accelerates rate‐determining aldehyde C─H activation in HMF oxidation and impedes O─H deprotonation in competing OER. This multi‐functional synergistic catalysis enables FDCA production at industrial‐level current densities without sacrificing FEFDCA ...
Junge Yang, Zhengjie Chen, Lili Zhang, Tao Zhang, Shida Bao, Jing Peng, Hui Pan, Hui‐Ming Cheng   +7 more
wiley   +1 more source

Territory-rooted curiosity and public service: the legacy of dr. Paul Pachas. [PDF]

Rev Peru Med Exp Salud Publica
Cabezas C.
europepmc   +1 more source