Results 301 to 310 of about 5,760,794 (363)

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Advanced Science, EarlyView.
This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin, Wenjing Liu, Wenjia Lu, Monong Zhao, Lin Cao, Zhiyu Li, Jubo Wang, Xi Xu, Hongxi Wu   +8 more
wiley   +1 more source

How and when paternalistic leadership influences service innovative behaviour while inhibiting counterproductive work behaviour among healthcare professionals: the roles of perceived supervisor support and public service motivation. [PDF]

J Health Organ Manag
Hussain M, Luu TT, Marjoribanks T.
europepmc   +1 more source

Super Time‐Resolved Tomography

Advanced Science, EarlyView.
A super time‐resolved tomography (STRT) approach is presented to reconstruct 4D X‐ray movies with an order‐of‐magnitude improvement in temporal resolution without sacrificing spatial resolution. By leveraging a physics‐informed deep learning algorithm that shares spatiotemporal features, STRT achieves high‐fidelity 3D reconstructions from sparse‐view ...
Zhe Hu, Zisheng Yao, Kalle Josefsson, Francisco García‐Moreno, Malgorzata Makowska, Yuhe Zhang, Pablo Villanueva‐Perez   +6 more
wiley   +1 more source

Digital economy and institutional dynamics: striving for equitable public service in a digitally transformed era. [PDF]

Front Public Health
Lyu Y, Xie J, Meng X, Wang X.
europepmc   +1 more source

Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression

Advanced Science, EarlyView.
Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li, Pushpa Dhilipkannah, Van K Holden, Ashutosh Sachdeva, Feng Jiang   +4 more
wiley   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

A study of market segmentation, government competition, and public service efficiency in China: Based on a semi-parametric spatial lag model. [PDF]

PLoS One
Yao L, Luo R, Yi X.
europepmc   +1 more source

Marlboro Central School District and Operations/ Food Service Unit, United Public Service Employees Union (2008) [PDF]

, 2008

core   +1 more source