Results 41 to 50 of about 1,152,837 (318)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Forecast of Hourly Airport Visibility Based on Artificial Intelligence Methods

Atmosphere, 2022
Based on the hourly visibility data, visibility and its changes during 2010–2020 at monthly and annual time scales over 47 international airports in China are investigated, and nine artificial-intelligence-based hourly visibility prediction models are ...
Jin Ding, Guoping Zhang, Shudong Wang, Bing Xue, Jing Yang, Jinbing Gao, Kuoyin Wang, Ruijiao Jiang, Xiaoxiang Zhu   +8 more
doaj   +1 more source

PRODUCTIVITY IN PUBLIC SERVICES [PDF]

Journal of Economic Surveys, 2009
Abstract This paper discusses issues arising in the measurement of productivity in public services. Compared to measuring productivity in the private sector difficulties arise because the output of public services is often unpriced and because some public services are consumed collectively.
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Public Service Media| Introduction ~ Public Service Media and Exposure Diversity

International Journal of Communication, 2015
Exposure diversity is a relatively new and as yet to be explicitly formulated objective of contemporary media policy. While it holds certain potential—in particular in the messy digital space characterized by abundance and exponentially increased user ...
Natali Helberger, Mira Burri
doaj  

A machine learning-based short-term forecasting method for heavy fog in Anhui Province of China

Scientific Reports
Based on hourly observations from expressway meteorological stations across Anhui Province and the fifth-generation atmospheric reanalysis (ERA5) data from the European Centre for Medium-Range Weather Forecasts (ECMWF) spanning from January 2011 to ...
Yan Sun, Chuanhui Wang, Yeqing Yao, Fei Wang, Jianping Zhou, Xiang Wang   +5 more
doaj   +1 more source

Hospitalisation rates differed by city district and ethnicity during the first wave of COVID-19 in Amsterdam, The Netherlands

BMC Public Health, 2021
Background It is important to gain insight into the burden of COVID-19 at city district level to develop targeted prevention strategies. We examined COVID-19 related hospitalisations by city district and migration background in the municipality of ...
Liza Coyer, Elke Wynberg, Marcel Buster, Camiel Wijffels, Maria Prins, Anja Schreijer, Yvonne T. H. P. van Duijnhoven, Alje P. van Dam, Mariken van der Lubben, Tjalling Leenstra   +9 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Correction to: Perceived barriers and enablers for preventing the spread of carbapenemase-producing gram-negative bacteria during patient transfers: a mixed methods study among healthcare providers

BMC Infectious Diseases, 2020
After publication of the original article [1], we have noticed that the word ‘Carbapenem-producing’ should be replaced with ‘Carbapenemase-producing’.
Eline van Dulm, Wendy van der Veldt, Katja Jansen-van der Meiden, Gerry van Renselaar, Lian Bovée, Jeanette Ros, Udi Davidovich, Yvonne van Duijnhoven   +7 more
doaj   +1 more source