Results 31 to 40 of about 5,734,629 (315)

Could Fire and Rescue Services identify older people at risk of falls? [PDF]

, 2011
Protecting or improving the efficiency and effectiveness of services while reducing costs in response to public sector funding reductions is a significant challenge for all public service organisations.
Anne H. Laybourne, David G. Whiting, Finbarr C. Martin, Gillespie, Karen Lowton, Lamb, McClure, Shai, Yardley   +8 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Transforming public services

Administration
The public service works to provide frontline and vital services to meet the needs of the people of Ireland. Working on behalf of the government in a diverse range of organisations, public servants play an established role in the economic and social life
Moloney David, Dwyer Rowena, Glavey Sarah, Sellars Dermot   +3 more
doaj   +1 more source

Impact of the COVID-19 pandemic on emergency and elective hip surgeries in Norway

Acta Orthopaedica, 2021
Background and purpose — Many countries implemented strict lockdown policies to control the COVID-19 pandemic during March 2020. The impacts of lockdown policies on joint surgeries are unknown.
Karin Magnusson, Jon Helgeland, Mari Grøsland, Kjetil Telle   +3 more
doaj   +1 more source

Publics, politics and power: Remaking the public in public services

, 2009
Challenges the notion that publicness and the public sphere is in decline, and analyses the emergence of new forms, sites and practices of publicness and the implications for public services.
Clarke, John, Newman, Janet
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Utilization of health care services before and after media attention about fatal side effects of the AstraZeneca vaccine: a nation-wide register-based event study

BMC Health Services Research, 2021
Background Survey studies have found that vaccinated persons tend to report more side effects after being given information about side effects rather than benefits.
Vilde Bergstad Larsen, Mari Grøsland, Kjetil Telle, Karin Magnusson   +3 more
doaj   +1 more source

Public sector restructuring and regional development: the impact of compulsory competitive tendering in the UK [PDF]

, 2002
This paper contributes to the analysis of contemporary public sector restructuring in the UK through an evaluation of the impact of the introduction of compulsory competitive tendering (CCT) for the provision of local public services.
Patterson, A., Pinch, P. L.
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source