Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte+10 more
wiley +1 more source
Sense of place attachment of user in public open space commercial building in West Jakarta [PDF]
The existence of public spaces dates back to Ancient Roman, Greek, and the present day. Although people today are known for their individualistic attitudes, they still need a place to communicate. However, public space is present everywhere possible, one
Anggiani M., D Ayudya R., Hirda A.
doaj +1 more source
Shutter, the Robot Photographer: Leveraging Behavior Trees for Public, In-the-Wild Human-Robot Interactions [PDF]
Deploying interactive systems in-the-wild requires adaptability to situations not encountered in lab environments. Our work details our experience about the impact of architecture choice on behavior reusability and reactivity while deploying a public interactive system. In particular, we introduce Shutter, a robot photographer and a platform for public
arxiv
The role of the rigged Hilbert space in Quantum Mechanics [PDF]
There is compelling evidence that, when continuous spectrum is present, the natural mathematical setting for Quantum Mechanics is the rigged Hilbert space rather than just the Hilbert space. In particular, Dirac's bra-ket formalism is fully implemented by the rigged Hilbert space rather than just by the Hilbert space.
arxiv +1 more source
Public space, public discourse, and public libraries [PDF]
The traditional mission of the public library—supporting the self-education of the citizenry in order that they may become fully participating members in a democratic society—has been devalued of late in favour of popularizing the library to attract more users. This shift has led to an emphasis on entertainment and marketing, and an abandonment of what
Alstad, Colleen, Curry, Ann
openaire +3 more sources
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source
Spaceprint: a Mobility-based Fingerprinting Scheme for Public Spaces [PDF]
In this paper, we address the problem of how automated situation-awareness can be achieved by learning real-world situations from ubiquitously generated mobility data.
Baratchi, Mitra+2 more
core +2 more sources
Maximal operator in Dunkl-Fofana spaces [PDF]
We generalize Wiener amalgam spaces by using Dunkl translation instead of the classical one, and we give some relationship between these spaces, Dunkl-Lebesgue spaces and Dunkl-Morrey spaces. We prove that the Hardy-Litlewood maximal function associated with the Dunkl operators is bounded on these generalized Dunkl-Morrey spaces.
arxiv
Social infrastructure and the public life of cities: Studying urban sociality and public spaces
Libraries, laundrettes, and lidos. Pizzerias, plazas, and playgrounds. Sidewalks, swimming pools, and schools. These are just some of the kinds of spaces and facilities that contribute to the public life of cities.
A. Latham, Jack Layton
semanticscholar +1 more source
Understanding and measuring mechanical signals in the tumor stroma
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz+3 more
wiley +1 more source