Results 131 to 140 of about 11,615,179 (305)

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen   +19 more
wiley   +1 more source

Fiscal Decentralization, the Composition of Public Spending, and Regional Growth in India [PDF]

open access: yes
In this paper, we present an analytical model for examining the growth impact of intergovernmental and intersectoral allocation of public expenditure.
Heng-fu Zou, Tao Zhang
core  

Public sector spending

open access: yesWelsh Economic Review, 2003
WER Editorial team
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

open access: yesAdvanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang   +11 more
wiley   +1 more source

TRENDS IN THE EVOLUTION OF ROMANIA'S PUBLIC EXPENDITURES IN THE PERIOD 2014 – 2023 [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie
Our analysis aims to capture the evolutions recorded by public expenditures in the reference interval, in order to formulate pertinent conclusions regarding the size of the state's financial effort and its distribution by objectives, actions and ...
POPEANGĂ VASILE NICOLAE
doaj  

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li   +15 more
wiley   +1 more source

Public Spending, Public Deficits, and Government Coalitions [PDF]

open access: yes
The study examines the relationship between types of government and level of public spending. There are two competing perspectives about the consequences of coalition governments on the size of public expenditures.
André Blais   +2 more
core  

Warfare and welfare? Understanding 19th and 20th century Central Government spending [PDF]

open access: yes, 2004
This paper evaluates theories aiming to explain the size and growth of government spending, develops a framework inclusive of the so-called guns vs. butter tradeoff effect, and offers insights especially for the period 1870-1938.
Eloranta, Jari
core  

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

open access: yesAdvanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray   +3 more
wiley   +1 more source

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