Results 41 to 50 of about 517,415 (305)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The Implementation of Special Sports Program in a Public Secondary School

Philippine Social Science Journal, 2020
The Special Program in Sports implemented in qualified public secondary high schools aims to develop the full potentials of athletes and prepare them for higher learning and work.
Ma. Fe Falcuto Agot
doaj   +1 more source

Access to public sports infrastructure in Poland as a preventive factor for cardiovascular diseases

Journal of Education, Health and Sport, 2023
Introduction: Cardiovascular diseases (CVDs) are a significant health concern globally, including in Poland. Physical activity has been identified as a crucial preventive factor for CVDs, and access to public sports infrastructure plays a vital role in ...
Adam Jasiura, Wiktoria Lipczyńska, Konrad Warchoł, Mateusz Gorzel   +3 more
doaj   +1 more source

Los usuarios de los centros deportivos públicos : una aproximación de segmentación sobre hábitos deportivos y satisfacción [PDF]

, 2016
La heterogeneidad de los usuarios de centros deportivos ha incrementado en los últimos años. Como consecuencia, estos clientes demandan servicios y un trato por parte del centro muy personalizados.
Aparicio Chueca, Pilar, Elasri Ejjaberi, Amal, Triadó Ivern, Xavier María   +2 more
core   +2 more sources

The performance of local authority sports facilities in England during a period of recession and austerity [PDF]

, 2018
This paper examines how public sport facilities in England, which are dependent on subsidy from local authorities, have performed during a period of recession and austerity.
Association of Public Service Excellence, Audit Commission, Audit Commission, Audit Commission, Blyth M., Booms B., Cabinet Office, Coalter F., DCMS, Girish Ramchandani, Gratton C., Gratton C., Kung S., Local Government Association, Mintel, Mintel, Schwarz E.C., Shia Ping Kung, Simon Shibli, Sport England   +19 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Designing First Aid Box Based on Material Aspects for Sport Facilities [PDF]

, 2019
Sports infrastructure is a place to working out. In doing so, people need to pay attention in safety and security measures because sports activities are vulnerable against accidents and injuries.
Muchlis, M. (Muchlis), Taufiq, K. N. (Khansa ), Yudiarti, D. (Diena )   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

GETTING OUT WHAT YOU PUT IN: An Evaluation of Public Investment in Irish Sport. RESEARCH SERIES NUMBER 4 OCTOBER 2008 [PDF]

, 2008
This paper presents an economic analysis of the returns to public investment in Irish sport, which has increased dramatically over the past decade. It combines figures on spending by central government and state agencies with a relatively new and rapidly
Lunn, Pete
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source